Mitigating mitochondrial mutational meltdown: can we save the species?

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• Professor Patrick Chinnery, Department of Clinical Neurosciences
• Monday 27 February 2023, 18:00-19:00
• Bristol-Myers Squibb Lecture Theatre, Department of Chemistry.

If you have a question about this talk, please contact Beverley Larner.

Please note change to start time of 18.00. Check website for latest updates and booking information http://www.cambridgephilosophicalsociety.org

Mitochondria are sub-microscopic organelles present in every cell. They convert the breakdown products of food into a form of energy the cell needs to function and survive. An unfortunate by-product is the generation of toxic oxygen free radicals that can damage DNA within each mitochondrion. With a limited capacity for repair, these mutations are passed down the maternal line, where they predispose to disease, can shorten our lifespan, and are threatening our own survival. New biological insights have cast light on the mechanisms involved, but is Homo sapiens facing mutational meltdown?

This talk is part of the Cambridge Philosophical Society series.

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