University of Cambridge > > Theory - Chemistry Research Interest Group > One becomes two: assemblies that split cells across evolution

One becomes two: assemblies that split cells across evolution

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If you have a question about this talk, please contact Lisa Masters. Meeting ID: 922 2072 0173 Passcode: 070083

The molecular machinery of life is largely created via self-organisation of individual molecules into functional larger-scaled assemblies. Such processes are multi-scale in nature and constantly driven far from thermodynamic equilibrium. Our group develops minimal coarse-grained models to investigate how driven macromolecular assemblies result in living machines, and how such processes can fail, leading to diseases.

Today I will present our research on computational modelling of active elastic protein filaments that dynamically change their conformations to reshape and cut cells. I will present the comparison of our simulation results to live cell data on reshaping processes across evolution — from cellular trafficking to cell division. I will finish with our recent efforts in computationally evolving assemblies that perform a desired function. Beyond their biological context, our models can help guide the design of artificial structures that are able to mimic life at the nanoscale.

This talk is part of the Theory - Chemistry Research Interest Group series.

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