Collective effects in epithelial cell elimination

Add to your list(s) Download to your calendar using vCal

• Dr. Romain Levayer (Institut Pasteur)
• Wednesday 29 September 2021, 17:00-18:00
• Webinar.

If you have a question about this talk, please contact Dr. Adrien Hallou.

To attend subscribe at: https://lists.cam.ac.uk/mailman/listinfo/ucam-tlm-talks

While the signals regulating apoptosis during development are rather well known, what sets the precise spatio-temporal distribution of cell death and the adjustment of cell elimination to local perturbations is not well understood. Similarly, how cells eventually engage in apoptosis and how the removal of cells from epithelial layer is orchestrated through cell extrusion remained poorly understood, especially in vivo. In this seminar, I will present our recent attempt to dissect these two layers of regulation in the Drosophila pupal notum (a single layer epithelium). I will first describe the contribution of EGFR /ERK modulations by mechanics in the competitive elimination of cells by oncogenic clones. I will then illustrate how the same pathway help to fine tune the spatio-temporal distribution of cell elimination during homeostasis through local and transient feedbacks. Eventually I will describe our latest data on the regulation of cell extrusion by a caspase dependent disassembly of microtubules and their unexpected contribution to epithelial shape stabilization.

This talk is part of the Theory of Living Matter Group series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge talks
• Department of Computer Science and Technology talks and seminars
• Hanchen DaDaDash
• Interested Talks
• PhD
• School of Technology
• Theory of Living Matter Group
• Trust & Technology Initiative - interesting events
• Webinar
• bld31

Note that ex-directory lists are not shown.