University of Cambridge > Talks.cam > Biophysical Seminars > The switch from choice to commitment: an example from HIV

The switch from choice to commitment: an example from HIV

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Anne Jacobs.

Gene expression is an example of a complex multistep cellular reaction, where variability in reaction outcome can convey distinct phenotypic properties. Results show that about 85% of genes across diverse promoters, genomic loci, and cell types (human and mouse) exhibit a high degree of rate-driven noise amplification. An additional cytoplasmic noise-amplification step leads to large variability in protein levels. This raises the important question of how efficient noise attenuation can be achieved, for example during human immunodeficiency virus (HIV) fate-commitment. Our data reveals that after a noise-driven event, HIV implements an efficient post-transcriptional negative-feedback which minimizes gene expression variability and stabilizes viral fate.

This talk is part of the Biophysical Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2021 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity