Fragments of stories: biophysics, chemical biology and drug discovery

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• Rod Hubbard, University of York and Vernalis
• Thursday 28 January 2021, 10:30-11:30
• https://zoom.us/j/98208866632?pwd=RW1QeWtUNzViZTRiVlBGU2d0b1Evdz09.

If you have a question about this talk, please contact Anne Jacobs.

The idea of screening a library of small compounds or fragments to find starting points for drug discovery was established more than 20 years ago. Many fragment-derived compounds are now in clinical trials, with a few now treating patients. The methods have recently been extended to chemical biology – using fragments as chemical tools to ask questions about a biological system.

In this seminar, I will briefly introduce the approach, but the main focus will be on selected stories on using fragments from work at Vernalis and York. As well as drug discovery, these include probing protein surfaces, identifying potential mechanisms for disrupting a molecular machine and improving the activity of industrial enzymes. Within these stories are useful lessons about the development and use of biophysical methods for detecting and characterizing the interaction of small molecules with proteins.

This talk is part of the Biophysical Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biophysical Seminar Series 2016/17
• Biophysical Seminars
• Department of Chemistry
• Featured lists
• School of Physical Sciences
• https://zoom.us/j/98208866632?pwd=RW1QeWtUNzViZTRiVlBGU2d0b1Evdz09

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