Hopfield barriers: following the energy in cellular information processing

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• Jeremy Gunawardena (Harvard Medical School)
• Tuesday 24 November 2020, 13:00-14:00
• via zoom, meeting ID 940-1803-7756.

If you have a question about this talk, please contact Patrick Pietzonka.

Zoom link: https://maths-cam-ac-uk.zoom.us/j/94018037756

It has long been understood that energy dissipation is fundamental to life and we know a great deal about the molecular components which acquire and transduce energy. The role of energy dissipation in force generation and directed movement is well understood but its role in information processing has been much less well studied. We will draw inspiration from John Hopfield’s classic analysis of kinetic proofreading to suggest the broader principle that any cellular information processing task has a performance limit set by thermodynamic equilibrium. We describe such Hopfield barriers in the context of gene regulation and discuss the challenges of “following the energy” to disentangle how energy dissipation away from equilibrium gives rise to information processing functionality.

This talk is part of the DAMTP Statistical Physics and Soft Matter Seminar series.

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• All CMS events
• DAMTP Statistical Physics and Soft Matter Seminar
• Soft Matter
• bld31
• via zoom, meeting ID 940-1803-7756

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