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Rare events and the flipping of genetic switches

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If you have a question about this talk, please contact Kevin Chalut.

Processes that happen randomly and infrequently, but with dramatic consequences, are notoriously difficult to simulate. I will discuss a method that we have developed, known as Forward Flux Sampling, for simulating these rare events in equilibrium or nonequilibrium systems. We have applied this method to the flipping of the genetic switch that controls the developmental transition from lysogeny to lysis in bacteriophage lambda. Our results lead to some general conclusions about stochastic modelling of gene regulatory networks.

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