The biophysical properties of microtubules and their technological potential

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• Prof. Jack Tuszynski, Department of Physics, University of Alberta, Edmonton, Canada
• Friday 10 October 2008, 14:15-15:15
• Small Lecture Theatre, Cavendish Laboratory.

If you have a question about this talk, please contact Jurij Kotar.

Microtubules are cylindrical cytoskeletal organelles whose building blocks are tubulin heterodimers. These protein polymers are ubiquitous in eukaryotic cells and play key roles in structural integrity, transport, motility, as well as division and differentiation phenomena. There are numerous isoforms of tubulin and their subtle differences in sequence and tertiary structure result in significantly different dynamical, biochemical and biophysical properties. In this talk, I will give an overview of the key biophysical and biochemical properties of tubulin and microtubules including their mechanics, polymerization kinetics, ligand binding and electrical effects. I will conclude by discussing some ideas regarding their yet- untapped potential as biotechnological devices.

This talk is part of the BSS Formal Seminars series.

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