Small, network models of effective connectivity in the human brain: evidence from fMRI and MEG

Add to your list(s) Download to your calendar using vCal

• Dr. Rik Henson (MRC Cognition and Brain Sciences Unit, Cambridge)
• Thursday 23 October 2008, 15:40-16:05
• Kaetsu Centre, New Hall.

If you have a question about this talk, please contact Duncan Simpson.

I will review recent methods for inferring changes in effective connectivity within small network models (typically a handful of interconnected regions) using human functional neuroimaging data from fMRI and EEG /MEG. These methods are based on Dynamic Causal Modelling (DCM), in which the parameters of a dynamic input-state-output system are identified within a Bayesian framework, given known deterministic inputs and observed outputs. The outputs (data) are derived from the (hidden) neural variables via modality-specific observer models (i.e, the “balloon model” of haemodynamics for fMRI, or equivalent current dipole models for EEG /MEG). The inputs represent experimental perturbations, with bilinear parameters in particular reflecting changes in connectivity induced by inputs. Inferences based on the posterior density of the connectivity parameters therefore reflect more than just functional connectivity. While those inferences are model-dependent, the Bayesian model evidence allows different models to be compared (particularly useful for EEG /MEG, where the data are fixed). While fMRI data provide greater spatial resolution, EEG /MEG data offer the exciting opportunity to explore regional dynamics and coupling at the millisecond level.

This talk is part of the Networks & Neuroscience series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• Biology
• CamBridgeSens
• Cambridge Neuroscience Seminars
• Cambridge talks
• Chris Davis' list
• Featured lists
• Horizon Forum
• Kaetsu Centre, New Hall
• Life Science
• Life Science Interface Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• Networks & Neuroscience
• Neuroscience
• Neuroscience Seminars
• Neuroscience Seminars
• Philosophy and History of Science
• Research Office Linked Events
• School of Physical Sciences
• School of Technology
• Stem Cells & Regenerative Medicine
• Trust & Technology Initiative - interesting events
• dh539
• jer64's list
• my_list
• other talks

Note that ex-directory lists are not shown.