Investigating the propagation and spreading of protein aggregates in C. elegans

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• Carmen Nussbaum-Krammer, Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH)
• Wednesday 20 March 2019, 10:30-11:30
• Department of Chemistry, Cambridge, Unilever lecture theatre.

If you have a question about this talk, please contact Gabriella Heller.

Many neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease are associated with the gradual accumulation and characteristic spreading of pathological proteins. Mechanisms underlying the prion-like propagation of protein aggregates remain, however, largely elusive. I will present our ongoing work using the nematode Caenorhabditis elegans as a model system to discover and examine cellular pathways and factors that influence the propagation and intercellular spreading of disease-associated proteins (e.g., α-Synuclein) in metazoans. A better understanding of these mechanisms might eventually identify new druggable targets for the treatment of neurodegenerative diseases.

This talk is part of the Biophysical Seminars series.

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