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Multicomponent Reactions in Peptide and Protein Chemistry

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  • UserProf Daniel García Rivera from the Faculty of Chemistry, University of Havana (Cuba)
  • ClockTuesday 22 May 2018, 16:00-17:00
  • HouseWolfson Lecture Theatre.

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Multicomponent reactions (MCRs) have lately evolved from versatile methods for the synthesis of small molecules to powerful tools for the post-synthetic derivatization of peptides and proteins. This lecture highlights the most recent multicomponent transformations conducted in my group to covalently modify peptides and proteins. These transformations include the multicomponent labeling and stapling of peptides by means of the Petasis and Ugi multicomponent reaction as well as the utilization of MCRs for the simultaneous lipidation/PEGylation and cyclization of peptides. Finally, our recent endeavor on the development of antibacterial glycoconjugate vaccine and anticancer vaccine candidates by means of a multicomponent polysaccharide-protein and lipid-protein conjugation is described.

This talk is part of the Biological Chemistry Research Interest Group series.

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