University of Cambridge > > Departmental Seminar Programme, Department of Veterinary Medicine > "Infection and Autoimmunity: Co-habitation may be a good thing."

"Infection and Autoimmunity: Co-habitation may be a good thing."

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If you have a question about this talk, please contact Laurence Tiley.

The development of most autoimmune diseases is under the control of many genes but additionally is regulated by environmental factors. This is exemplified by studies of identical twins where the concordance rate for development of Type 1 diabetes is around 40%. Several autoimmune diseases, including Type 1 diabetes, are increasing in incidence in the developed world at a rate faster than can be accounted for by genetic change. Our study of environmental factors modulating autoimmunity has highlighted a key role for infection in reducing the incidence of Type 1 diabetes. We think that protection from diabetes arises through an interaction between the infectious agent and the innate immune system such that circuits which regulate the autoimmune response are reinforced.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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