CTLA-4 regulation of T-cell immunity

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• Professor Christopher E. Rudd, Dept. of Pathology, University of Cambridge
• Wednesday 17 October 2007, 16:30-17:30
• Lecture Theatre 1, Department of Veterinary Medicine.

If you have a question about this talk, please contact Laurence Tiley.

The coreceptor cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is pivotal in regulating the threshold of signals during T cell activation, although the underlying mechanism is still not fully understood. Using in vitro migration assays and in vivo two-photon laser scanning microscopy, we showed that CTLA -4 increases T cell motility and overrides the T cell receptor (TCR)-induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells. This event led to reduced contact periods between T cells and antigen-presenting cells that in turn decreased cytokine production and proliferation. In addition, CTLA -4 ligation prevented TcR complex induction of ZAP -70 microclusters needed for the tyrosine phosphorylation cascade in T-cells. These results suggest a fundamentally different model of reverse stop signaling, by which CTLA -4 modulates the threshold for T cell activation and protects against autoimmunity.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 1, Department of Veterinary Medicine
• Vet School Seminars

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