Rapid adaptation and the predictability of evolution

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• Richar Neher, Max Planck Institute for Developmental Biology
• Wednesday 25 May 2016, 16:00-17:00
• Lecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

Evolution is simple if adaptive mutations appear one at a time. However, in large microbial populations many mutations arise simultaneously resulting in a complex dynamics of competing variants. I will discuss recent insight into universal properties of such rapidly adapting populations and compare model predictions to whole genome deep sequencing data of HIV -1 populations at many consecutive time points. Genetic diversity data can further be used to infer fitness of individuals in a population sample and predict successful genotypes. We validate these prediction using historical influenza virus sequence data. Successful predictions of the composition of future influenza virus population could guide strain selection for seasonal influenza vaccines.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 2, Department of Veterinary Medicine
• Vet School Seminars

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