University of Cambridge > > Departmental Seminar Programme, Department of Veterinary Medicine > Finding cancer drivers in mouse, man and dog

Finding cancer drivers in mouse, man and dog

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Cross-species analysis of cancer genomes has contributed significantly to our understanding of cancer evolution and the identification of cancer driver genes. We have been using a combination of approaches including genome sequencing of human and mouse tumours, transposon screens and forward genetics in the mouse, and more recently the sequencing of dog tumours to identify cancer drivers. Another aspect of our work is the use of large-scale mouse genetics to find disease genes. In particular we have been using the stream of knockout mice generated by the Sanger Mouse Genetics Project to identify host factors influencing tumour growth and metastatic spread. So far we have screened over 500 knockout lines identifying components of the immune system that influence tumour growth.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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