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Fc Receptors: Critical regulators of antibody biology and therapy

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If you have a question about this talk, please contact Dr Tennie Videler.

Mark Cragg , Southampton, hosted by Leo James

Monoclonal antibodies (mAb) represent a growing class of ‘block-buster’ cancer drugs, led by established reagents such as rituximab, trastuzumab, and bevacizumab. Despite such success, we are only now starting to understand how these drugs work and therefore how they can be augmented for better efficacy. We have understood for some time that Fc gamma receptors (FcR) on effector cells are critical for the in-vivo efficacy of direct-targeting mAb. However, recent data from our lab and others indicates that the situation is more complex than first appreciated. In this talk, data will be presented revealing novel ways in which the biology of FcR can regulate mAb activity with clear implications for subsequent design of future reagents. In particular the inhibitory FcR (CD32B) will be explored as a target for manipulating various forms of immunotherapy.

This talk is part of the Cambridge Immunology series.

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