Molecular mechanisms of synapse degeneration in prion and Alzheimer's disease

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• Dr Clive Bate, Pathology & Infectious Diseases, The Royal Veterinary College
• Wednesday 15 May 2013, 16:15-17:15
• Lecture Theatre 1, Department of Veterinary Medicine.

If you have a question about this talk, please contact Suzy Blows.

Synapse degeneration is the key event leading to memory failure in Alzheimer’s and prion diseases. Prions and amyloid-beta42 (thought to be the major neurotoxin in Alzheimer’s disease) trigger synapse damage in cultured neurons. In this talk I will discuss the molecular mechanisms of synapse damage in response amyloid-beta42 and prions including experimental data implicating the role of specific receptors, lipid rafts and signalling cascades. I will then discuss possible intervention strategies based on the manipulation of these molecular pathways.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 1, Department of Veterinary Medicine
• Vet School Seminars

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