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Rho GTPases in pulmonary vascular remodelling

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Rho GTPases, best known for their regulatory role in actin dynamics, stimulate a variety of processes important in control of vascular function, including morphogenesis, migration, cell proliferation and adhesion, cell survival, gene expression, vesicle transport and microparticle formation. Recent data implicate Rho GTPase RhoB in the regulation of pulmonary vascular remodelling in pulmonary hypertension. This lecture will discuss signalling mechanisms involved in Rho-induced pulmonary vascular dysfunction and identify potential targets for pharmacological intervention.

This talk is part of the Vascular Biology Research Seminars series.

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