Deconstructing Metastasis - Epigenetic Expansion of the VHL-HIF Signal Output Drives Renal Cancer Progression

Add to your list(s) Download to your calendar using vCal

• Dr Sakari Vanharanta, Cancer Biology and Genetics Programme, Memorial Sloan-Kettering Cancer Centre, USA
• Friday 01 March 2013, 14:30-15:30
• Sackler Lecture Theatre, CIMR, Level 7.

If you have a question about this talk, please contact Dr Ireena Dutta.

Clear cell renal cancer, the most common form of kidney cancer, is initiated by inactivating mutations in the VHL tumour suppressor gene. This leads to the activation of HIF transcription factors, which is essential for renal cancer development, but does not automatically lead to the metastatic spread of the tumour. New results show that in some patients, epigenetic alterations can allow the expansion of the VHL -HIF transcriptional output, leading to the activation of metastatic traits.

This talk is part of the MRC Cancer Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CCC talks for website
• Liam
• MRC Cancer Unit Seminars
• Sackler Lecture Theatre, CIMR, Level 7

Note that ex-directory lists are not shown.