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Deconstructing Metastasis - Epigenetic Expansion of the VHL-HIF Signal Output Drives Renal Cancer Progression

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If you have a question about this talk, please contact Dr Ireena Dutta.

Clear cell renal cancer, the most common form of kidney cancer, is initiated by inactivating mutations in the VHL tumour suppressor gene. This leads to the activation of HIF transcription factors, which is essential for renal cancer development, but does not automatically lead to the metastatic spread of the tumour. New results show that in some patients, epigenetic alterations can allow the expansion of the VHL -HIF transcriptional output, leading to the activation of metastatic traits.

This talk is part of the MRC Cancer Unit Seminars series.

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