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Exploiting cancer stem cells for the identification of mediators involved in brain tumorigenesis

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If you have a question about this talk, please contact Dr Ireena Dutta.

Brain tumors are characterized by rapid growth characteristics and extreme invasive behavior, thus being inherently resistant to conventional therapy. Therefore, improvement of treatment options for patients with BTs is imperative. BTs comprise subpopulations of cancer stem cells (CSCs), which are capable to initiate and sustain tumor development. These CSCs phenocopy the tumors of origin, and, as such, are envisioned as a novel and valuable preclinical model to develop new therapeutic approaches for BTs. In particular, gene expression profiles of BT CS Cs, which are characterized by cell line-specific molecular and phenotypic traits, can be exploited in order to identify CSC -restricted molecular mediators, which hold significant advantages in terms of cell-targeting specificity and therapeutic exploitability.

This talk is part of the MRC Cancer Unit Seminars series.

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