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What can we learn from sequencing thousands of human genomes?

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New DNA sequencing technologies have lowered costs per base sequenced by five orders of magnitude since the reference human genome was completed 10 years ago. Taking advantage of this, projects such as the 1000 Genomes Project and UK10K are sequencing the genomes of thousands of people to study genetic variation and its relationship to the differences we observe between people at the macroscopic level. Using the same basic technologies we can also now collect unprecedented amounts of data about gene and genome function. Beyond the data, how will this change our knowledge of human biology, and will the possibility of obtaining personal genome sequences have major consequences for individuals?

This talk is part of the Trinity College Science Society (TCSS) series.

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