Next Generation Genome Engineering using CompoZr Zinc Finger Nucleases

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• Gurpreet Balrey & Mark Skinner, Sigma Life Sciences
• Wednesday 10 October 2012, 16:30-17:30
• Lecture Theatre 1, Department of Veterinary Medicine.

If you have a question about this talk, please contact Suzy Blows.

Zinc finger nucleases (ZFNs) are a class of engineered DNA -binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations. Double-strand breaks are important for site-specific mutagenesis in that they stimulate the cell’s natural DNA -repair processes, namely homologous recombination and Non-Homologous End Joining (NHEJ). Using well-established and robust protocols, these cellular processes can be harnessed to generate precisely targeted genomic edits resulting in cell lines, including somatic cell lines, with targeted gene deletions (Knockouts), integrations, or modifications. Sigma® Life Science has applied the revolutionary CompoZr® Zinc Finger Nuclease technology to create an unparalleled range of genetically modified mammalian cell lines , rat, mouse and rat models and most recently engineered human inducible pluripotent stem cell lines (iPSCs) for use in areas such as basic research, target validation, drug discovery and drug development.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 1, Department of Veterinary Medicine
• Vet School Seminars

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