University of Cambridge > > Immunology and Medicine Seminars > Bridging the Gap: Computational Biology and Trafficking of MHC Class I

Bridging the Gap: Computational Biology and Trafficking of MHC Class I

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The surface expression of MHC class I molecules at least partially depends on the endoplasmic reticulum protein, tapasin, which helps them bind peptides of the appropriate length and sequence. Why do class I molecules need tapasin? We have used molecular dynamics, a novel in silico approach, to generate a hypothesis, and then tested it using biochemical and cell biological methods. The surprising finding is that some class I molecules are intrinsically disordered unless tapasin structures their binding site. A comprehensive unifying scheme of tapasin function that takes other data from the literature into account will be presented, and implications for the cellular quality control of MHC class I will be discussed.

This talk is part of the Immunology and Medicine Seminars series.

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