Bridging the Gap: Computational Biology and Trafficking of MHC Class I

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• Professor Sebastian Springer, Jacobs University, Bremen, hosted by John Trowsdale
• Friday 07 October 2011, 13:00-14:00
• Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

If you have a question about this talk, please contact Liz Williams.

The surface expression of MHC class I molecules at least partially depends on the endoplasmic reticulum protein, tapasin, which helps them bind peptides of the appropriate length and sequence. Why do class I molecules need tapasin? We have used molecular dynamics, a novel in silico approach, to generate a hypothesis, and then tested it using biochemical and cell biological methods. The surprising finding is that some class I molecules are intrinsically disordered unless tapasin structures their binding site. A comprehensive unifying scheme of tapasin function that takes other data from the literature into account will be presented, and implications for the cellular quality control of MHC class I will be discussed.

This talk is part of the Cambridge Immunology Network Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Immunology Network Seminar Series
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• LMB
• Liam
• Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research

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