Comprehensive profiling of anaesthetised brain dynamics across phylogeny

Add to your list(s) Download to your calendar using vCal

• Dr Andrea Luppi
• Thursday 15 May 2025, 15:00-16:00
• Online.

If you have a question about this talk, please contact Sarah Morgan.

Intrinsic dynamics of neuronal circuits shape information processing. Combining neuroimaging with causal perturbation offers the opportunity to understand how local dynamics mediate the link between neurobiology and functional repertoire. We compile a unique dataset of multi-scale neural activity during wakefulness and anaesthetic-induced suppression of information processing encompassing human, macaque, marmoset, mouse and nematode. Applying massive feature extraction, we comprehensively characterise local neural dynamics across >6,000 time-series features. Using dynamics as a common space for cross-species comparison reveals a phylogenetically conserved dynamical profile of anaesthesia, characterised by reduced intrinsic timescales and dampened inter-regional synchrony, confirmed by computational modelling. Spatially, this profile covaries with conserved transcriptional profiles of neurotransmission across human, macaque and mouse cortex. This dynamical regime is experimentally reversed in vivo by deep-brain stimulation of the macaque centromedian thalamus, restoring behavioural responsiveness. Altogether, comprehensive dynamical phenotyping reveals that across species and scales, anaesthetics induce spatiotemporal isolation of local neural activity.

This talk is part of the Making connections- brains and other complex systems series.

This talk is included in these lists:

• Biology
• Cambridge Neuroscience Seminars
• Cambridge talks
• Chris Davis' list
• Featured lists
• Life Science
• Life Sciences
• Making connections- brains and other complex systems
• Neuroscience
• Neuroscience Seminars
• Neuroscience Seminars
• Online
• Stem Cells & Regenerative Medicine
• dh539

Note that ex-directory lists are not shown.