Computational Methods to Design Broad-Spectrum Medical Countermeasures Against Antigenically Diverse Pathogens

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• Phil Palmer, Department of Veterinary Medicine
• Wednesday 05 February 2025, 16:00-17:00
• LT1, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

Abstract Antigenically diverse pathogens, such as coronaviruses, highlight the need for broad-spectrum vaccines that protect against a range of variants. In this talk, I will introduce Spectravax, a computational framework for designing vaccines optimised for genetic diversity in both hosts and pathogens. Using Spectravax, I designed a nucleocapsid antigen that elicited immune responses to SARS -CoV-1, SARS -CoV-2, and MERS -CoV—the three coronaviruses responsible for major outbreaks since 2002.

Bio Phil recently submitted his PhD thesis, which he completed in Prof. Jonathan Heeney’s lab, focusing on computational methods to design broad-spectrum vaccines and antibodies. He previously worked as a bioinformatician in industry, was a visiting researcher at MIT , and completed his undergraduate degree in Biology at the University of Southampton.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• LT1, Department of Veterinary Medicine
• Vet School Seminars

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