University of Cambridge > > Morphogenesis Seminar Series > You are not encoded - a biological theory of form

You are not encoded - a biological theory of form

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  • UserAlan Rodrigues, Rockefeller University
  • ClockMonday 20 May 2024, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact Jia CHEN.

Presenter: Alan Rodrigues (Co-director, The Laboratory of Morphogenesis, Rockefeller University)

Abstract: In recent decades, much progress has been made in understanding how genes within cells contribute to organ-specific fates or disease phenotypes. However, it is becoming more widely acknowledged that increasing understanding at the molecular scale has not been sufficient to fully grasp how tissues comprised of thousands of cells generate their structures. To address this gap, the Shyer/Rodrigues lab centers its studies on the behavior of cell collectives in vertebrate tissues. Using novel collective cell behavioral assays and the skin as a model, we find that emergent biophysical properties arise at the ‘supra’-cellular scale during organ development. Such emergent properties then serve to shape the skin. Our findings indicate that epigenetic processes beyond the cell scale can organize morphogenesis in vertebrate tissues. Finally, uncovering such epigenetic processes has allowed us to provide an account of morphogen function that re-envisions canonically accepted roles of these chemical cues.

Zoom link: Join Zoom Meeting Meeting ID: 879 3994 3699

This talk is part of the Morphogenesis Seminar Series series.

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