Modelling active morphogenesis of patterned epithelia

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• Diana Khoromskaia (Crick Institute, London)
• Monday 24 April 2023, 14:30-15:30
• Online.

If you have a question about this talk, please contact Dr. Wolfram Pönisch.

https://us06web.zoom.us/j/82089026611?pwd=L2FyclJFL2lYR0J3SFBDbHQyUFp6UT09

Shape transformations of epithelial tissues in three dimensions are crucial for embryonic development and in vitro organoid growth and can result from active forces generated within the cytoskeleton of the epithelial cells. How the interplay of local differential tensions with tissue geometry results in tissue-scale morphogenesis remains an open question.

We present a model of epithelial sheets as active viscoelastic surfaces and study their deformation under patterned internal tensions and bending moments. In addition to isotropic effects, we take into account nematic alignment in the plane of the tissue, which gives rise to shape-dependent, anisotropic active tensions and bending moments. We present phase diagrams of the mechanical equilibrium shapes of pre-patterned closed shells and explore their dynamical deformations. Our results show that a combination of nematic alignment and gradients in internal tensions and bending moments is sufficient to reproduce basic building blocks of epithelial morphogenesis, including fold formation, budding, neck formation, flattening, and tubulation.

This talk is part of the Morphogenesis Seminar Series series.

This talk is included in these lists:

• Graduate-Seminars
• Morphogenesis Seminar Series
• Online

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