Characterisation of structural variation in 24 breast cancer genomes using paired-end sequencing on the Illumina Genome Analyser

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• Phil Stevens, Wellcome Trust Sanger Institute
• Wednesday 27 May 2009, 15:00-16:00
• Cancer Research UK Cambridge Research Institute, Room 215.

If you have a question about this talk, please contact Katrien Van Look.

If you would like to attend, please e-mail: katrien.vanlook@cancer.org.uk

We have used massively parallel paired end sequencing on the Illumina G A to reconstruct the genomic landscape of 24 breast cancer genomes, through the identification and characterization of ~2200 cancer-specific structural rearrangements. These studies have revealed considerable complexity in the patterns of structural variation, identified 19 novel, expressed in-frame gene fusions and unveiled new insights into the complex structure of amplicons.

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