University of Cambridge > > Departmental Seminar Programme, Department of Veterinary Medicine > Mycobacterium tuberculosis genome economization for pathogenesis: “More from less for more”

Mycobacterium tuberculosis genome economization for pathogenesis: “More from less for more”

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  • UserProf Seyed E. Hasnain, Indian Institute of Technology, Delhi and Sharda University, Greater Noida World_link
  • ClockThursday 07 July 2022, 16:00-17:00
  • HouseVenue to be confirmed.

If you have a question about this talk, please contact Fiona Roby.

Room changed - will be Seminar Rooms 2/3, Pathology Block, Department of Veterinary Medicine.

Abstract: Mycobacterium tuberculosis (M.tb) is the deadliest bacterial pathogen known to humanity causing the disease TB, taking the largest toll of human lives globally with a person dying every 15-20 seconds despite the fact that TB is completely curable if diagnosed timely and treated properly. This problem is further compounded by the development of drug resistance, to the extent of total drug resistance, HIV AIDS co-infection and the accompanying TB-IRIS and the impending impact of the emerging diabetes epidemic and of late the COVID -19 pandemic. M.tb has undergone reductive evolution, over millions of years, into a very slim and trim genomic and functional architecture. Not only has it shed much of its genome, but has balanced this genome deficit by resorting to very intelligent survival strategies such as gene co option, moon lighting and molecular mimicry.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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