Targeting protein aggregate clearance pathways to slow neurodegeneration in prion disorders

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• Dr Christina J. Sigurdson, Center for Veterinary Sciences and Comparative Medicine, UC San Diego
• Wednesday 28 April 2021, 16:00-17:00
• Venue to be confirmed.

If you have a question about this talk, please contact Fiona Roby.

Experimental studies indicate prion aggregates rapidly transit throughout the central nervous system, yet the relationship between the prion structure and genetic modifiers that impact aggregate spread are poorly understood. We and others previously showed profound differences in the neuroinvasion of prions, depending on the strain. Using a series of established and new mouse models to alter the extracellular matrix or the prion protein, we investigated the determinants of prion propagation through the neuron and through the CNS .

Chaired by Dr Raymond Bujdoso

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Venue to be confirmed
• Vet School Seminars

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