University of Cambridge > > Babraham Seminar > The protein kinase DYRK2 as a new regulator of protein homeostasis

The protein kinase DYRK2 as a new regulator of protein homeostasis

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  • UserDr Laureano de la Vega; CRUK Fellow and Group Leader, School of Medicine, Division of Cellular Medicine, University of Dundee
  • ClockWednesday 12 August 2020, 12:00-13:00
  • HouseZoom Seminar.

If you have a question about this talk, please contact Bobbie Claxton.

This seminar will be online via zoom - Please ensure that you mute your microphones when joining the presentation

Cancer cells are exposed to high levels of cellular stress and they depend on stress-relief pathways in order to survive and proliferate. To survive the proteotoxic stress produced by the accumulation of excess and often misfolded proteins, cancer cells can either a) increase protein folding capacity (controlled by the transcription factor HSF1 ) or b) increase protein degradation (by the autophagy and ubiquitin proteasome system). In this talk I will show how in triple negative breast cancer (TNBC) cells, the dual-speci´Čücity tyrosine-regulated kinase 2 (DYRK2) is an upstream positive regulator of both HSF1 and the proteasome. This presents DYRK2 as a positive regulator of two main mechanisms by which aneuploid cells adapt, survive and become malignant, and thus highlights this kinase as a potential therapeutic target.

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This talk is part of the Babraham Seminar series.

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