Questions around cellular plasticity: naive pluripotency and epigenetic rejuvenation by reprogramming

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• Prof. Manuel Serrano; ICREA Professor, Institute for Research in Biomedicine (IRB Barcelona), Spain
• Wednesday 15 July 2020, 12:00-13:00
• Zoom Seminar.

If you have a question about this talk, please contact Bobbie Claxton.

This seminar will be online via zoom

My lab has a general interest in cell plasticity, how it is regulated, and its beneficial or maladaptive implications. I will present two recent projects. First, I will talk about how the transcriptional machinery regulates cellular plasticity. We have identified an actionable kinase, CDK8 , and we show that chemical inhibition of CDK8 reinforces enhancers and thereby cell identity, resulting in a loss of plasticity. We apply this to solve a long-standing problem that is the stabilisation of human pluripotent stem cells in their naïve state. Then, I will present our data in collaboration with the laboratory of Wolf Reik on the use of the Yamanka factors to trigger plasticity in vivo in a regulated manner. I will show that transient in vivo expression of the Yamanaka factors induces epigenetic rejuvenation of tissues.

Join us: https://zoom.us/j/97446595226?pwd=NkZNTkg3V3d0UEszQ0gyKzRFVm9HZz09

Meeting ID: 974 4659 5226 Password: 014403

This talk is part of the Babraham Seminar series.

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