Regulation of B cell responses by distinct populations of T cells

Add to your list(s) Download to your calendar using vCal

• Dr Nicolas Fazilleau; Deputy director of The Physiopathology Center of Toulouse-Purpan
• Wednesday 17 July 2019, 12:00-13:00
• Babraham - The Cambridge Building - Kings Hedges Room.

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this seminar, please contact us to arrange site access.

Maturation of B cells in Germinal Centers (GC) is a hallmark in adaptive immunity and the basis of successful vaccines that protect us against lethal infections. Therefore it is key to understand how B cell selection takes place in GCs in order to develop new and fully protective vaccines. The cellular mechanisms that control B cell selection are performed by different T cell populations. On one side, cognate interaction of B cells with T follicular helper (Tfh) cells promotes survival, proliferation, mutagenesis and terminal differentiation of GC B cells. On the other hand, regulatory T cells have also been reported within GC and interfere with T cell help for antibody production. These cells have been called T Follicular regulatory cells (Tfr). During this seminar, we will discuss the established phenotypes and functions of Tfh cells and Tfr cells, emphasizing the complementary role of these two cell populations in the GC.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Cambridge Building - Kings Hedges Room
• Babraham Seminar
• Graduate-Seminars
• se393's list

Note that ex-directory lists are not shown.