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The Ultrastructure of Retinal Circuitry in Health and Disease

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If you have a question about this talk, please contact Dr Romina Vuono .

We are currently exploring the fundamental retinal circuitry using 2nm/pixel ultrastructural connectomics approaches in normal retina, and in human and animal models of retinal degeneration. Specifically, we are interested in network topology of precise retinal circuitry and using that as a ground truth to compare how circuit topologies are altered in retinal degenerative diseases. In addition to revealing the fundamental framework of neural connectivities that electrophysiology and molecular approaches can build upon, there are implications for the preservation or modification of circuit topologies in therapeutic interventions for vision loss via gene therapy, survival factors, pharmacologic, optogenetic, bionic or biological implants.

This talk is part of the Clinical Neurosciences Seminars series.

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