Male germline epigenetic priming for future development

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• Dr Shinichi Tomizawa; Department of Histology and Cell Biology, Yokohama City University
• Thursday 07 March 2019, 13:00-14:00
• Babraham - The Cambridge Building - The Kings Hedges Room.

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Evidence suggests that mammalian male germ cells carry the epigenome primed for embryonic development. However, the mechanisms underlying establishment and transmission of germline epigenetic information remain unclear. Recently, we found that the histone methyltransferase Kmt2b conveys H3K4me3 to prime the spermatogonial stem cell epigenome for spermatogenesis and embryonic development in two distinguishable ways. Because Kmt2b also primes the ES cell chromatin, we propose that Kmt2b has the capacity to prime stem cells epigenetically.

This talk is part of the Babraham Seminar series.

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