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Male germline epigenetic priming for future development

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Evidence suggests that mammalian male germ cells carry the epigenome primed for embryonic development. However, the mechanisms underlying establishment and transmission of germline epigenetic information remain unclear. Recently, we found that the histone methyltransferase Kmt2b conveys H3K4me3 to prime the spermatogonial stem cell epigenome for spermatogenesis and embryonic development in two distinguishable ways. Because Kmt2b also primes the ES cell chromatin, we propose that Kmt2b has the capacity to prime stem cells epigenetically.

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