Chaperone networks coping with protein aggregates and amyloids

Add to your list(s) Download to your calendar using vCal

• Bernd Bukau, Center for Molecular Biology of Heidelberg University (ZMBH)
• Friday 23 November 2018, 15:00-16:00
• The Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building, CIMR, Addenbrooke's Site.

If you have a question about this talk, please contact John Skidmore.

Misfolded proteins are sticky and tend to form intracellular aggregates underpinning age-related deterioration and diseases including cancer and neurodegeneration. Normally, multi-tiered cellular quality control systems monitor and repair protein damage, limiting aggregation. Severe stress however overloads these systems allowing aggregates to accumulate. This activates a cellular machinery which mediates the organized aggregation of misfolded proteins as well as the subsequent solubilisation and refolding of aggregated proteins. This machinery plays a pivotal role in cell survival under protein folding stress and in counteracting disease and age-associated cell toxicities. Small heat shock proteins (sHsp) constitute an evolutionary conserved yet diverse family of chaperones acting as first line of defense against proteotoxic stress. They promote the storage of misfolded proteins in native-like conformation facilitating disaggregation by ATP dependent chaperone systems. In plants, fungi and bacteria the central disaggregation machinery is a powerful bi-chaperone system comprised by the AAA + disaggregase Hsp100 (Hsp104, ClpB) and the cooperating Hsp70 chaperone system. Metazoan cells lack Hsp100 disaggregases, but have evolved a potent Hsp70-based disaggregation machinery which relies on synergistic action of Hsp70 and its co-chaperones. This activity has broad specificity and can even disassemble amyloid fibrils. This seminar provides insights into the working mode of the eukaryotic disaggregases in dealing with aggregates and amyloids.

This talk is part of the Cambridge Neuroscience Seminars series.

This talk is included in these lists:

• Biology
• Cambridge Neuroscience Seminars
• Cambridge talks
• Chris Davis' list
• Featured lists
• Life Science
• Life Sciences
• Neuroscience
• Neuroscience Seminars
• Neuroscience Seminars
• Stem Cells & Regenerative Medicine
• The Sackler Lecture Theatre (Level 7) Wellcome Trust/MRC Building, CIMR, Addenbrooke's Site
• dh539

Note that ex-directory lists are not shown.