The HIV glycan shield as a target for broadly neutralizing antibodies

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• Dr Katie Doores, MRC Career Development Fellow, Department of Infectious Diseases, King's College London
• Wednesday 03 October 2018, 16:00-17:00
• Lecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

The elicitation of broadly neutralizing antibodies (bnAbs) is a key step for the development of a successful an HIV vaccine. Approximately 10-30% of HIV infected individuals do elicit broadly neutralizing antibodies that have been shown to protect against infection in macaque models. Isolation and epitope characterization of these antibodies reveal conserved regions of the virus envelope that can be targeted through vaccine design. The HIV envelope glycoprotein, gp120, is one of the most heavily glycosylated proteins known. The high density of glycans on gp120 limits their processing during biosynthesis, leading to the formation of a high-mannose patch on gp120. The density and heterogeneity of the glycans impede neutralizing antibody (NAb) recognition of Env but, paradoxically, some of the most potent broadly active bNAbs recognize epitopes involving this glycan shield. Here I will discuss our recent studies on the characterization of the HIV glycan shield and the development of HIV glycan-binding HIV bnAbs in a longitudinal cohort of HIV infected individuals.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Disease
• Cambridge Infectious Diseases
• Departmental Seminar Programme, Department of Veterinary Medicine
• Lecture Theatre 2, Department of Veterinary Medicine
• Vet School Seminars

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