University of Cambridge > Talks.cam > Babraham Seminar > Drosophila Kinome and Genome-wide RNAi screens reveal novel regulators of epigenetic cell memory

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Drosophila Kinome and Genome-wide RNAi screens reveal novel regulators of epigenetic cell memory

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this talk, please contact us to arrange site access

Cell fate determination, a fundamental aspect of development in multicellular eukaryotes, relies on establishment of cell-type specific gene expression patterns during early development. Once established, these patterns are subsequently maintained by two groups of proteins known as Polycomb group (PcG) and Trithorax group (TrxG). Both the PcG and TrxG associate with chromatin in the form of multimeric protein complexes to maintain either a silent or an active states of gene expression, respectively. These states are epigenetically inherited through cell division and are referred to as cellular memory, a phenomenon which plays a fundamental role in cell lineage commitment and differentiation. We have successfully established a cell based reporter system in Drosophila which is sensitive to modulation of PcG and TrxG genes. We have exploited our cell based assay to perform kinome and genome-wide RNAi screens in Drosophila cells to discover novel regulators of the epigenetic cell memory. Genetic and molecular characterization of candidate genes discovered in genome-wide RNAi screen have revealed additional histone modifications like phosphorylation and acetylation which influence epigenetic cell memory. In addition to previously known H3K27 trimethylation and H2A K119ub, a combinatorial act of additional histone modifications will be discussed to maintain epigenetic cell memory.

This talk is part of the Babraham Seminar series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

The Forensic Use of Bioinformation Graduate Students and Postdocs (GRASP) Forum

Other talks

Zone 6 Convention PROFESSIONAL REGISTRATION WORKSHOP Perception of Visual Space Babraham Distinguished Lecture - Endoplasmic reticulum turnover via selective autophagy Discovery of a 4-sigma deviation from the Concordance Model of Cosmology using the Hubble Diagram of Quasars. Full-field optical metrology
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity