Bob Groves - I'm Glovin' It and Alex Routh - How do LEA proteins operate?

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• Alexander F. Routh, BP Institute and Bob Groves, BP Institute visitor
• Thursday 17 May 2018, 11:30-12:30
• Open Plan Area, BP Institute, Madingley Rise CB3 0EZ.

If you have a question about this talk, please contact Catherine Pearson.

Bob Groves – I’m Glovin’ It Aqueous polymer dispersions are versatile materials used in the production of many familiar items, including paints, tyres, adhesive and carpets. Another member of this family is the humble rubber glove, made in billions per year.

In this talk, the nature and production of synthetic polymer dispersions is explained. Reasons are suggested why one such dispersion, known as nitrile latex, has become widely used to make rubber gloves, including the ubiquitous purple glove. Glove manufacture is discussed and some recent advances in understanding its details are presented. Current work in BPI , aimed at reducing the environmental impact of glove production, is described.

Alex Routh – How do LEA Proteins Operate? Some organisms can survive freezing and thawing. One example is a nematode and how they survive is not known. It is hypothesised that the nematodes exude intrinsically disordered proteins and these protect globular proteins from denaturating during freezing. We grow nematode intrinsically disordered proteins in e-coli and show that it does indeed protect a model globular protein (pig heart citrate synthase) through many rounds of freeze-thaw. Using multiple techniques we find no interaction between the two proteins.

We deuterated the intrinsically disordered protein and using neutron reflectivity we show how the IDP preferentially adsorbs at the air-water interface. This stops the citrate synthase from unfolding at the hydrophobic interface.

This talk is part of the Institute for Energy and Environmental Flows (IEEF) series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Cambridge Energy Seminars
• Department of Earth Sciences seminars
• Institute for Energy and Environmental Flows (IEEF)
• NanoDTC Energy Materials Talks
• Open Plan Area, BP Institute, Madingley Rise CB3 0EZ
• history
• ps635

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