Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Epigenetics and genome plasticity in the human fungal pathogen Candida albicans

Hosted by Paul Lehner, Speaker: Alessia Buscaino

User Alessia Buscaino, University of Kent.

Friday 04 November 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“B cell selection in germinal centres”

Hosted by Menna Clatworthy, Speaker: Kai Toellner

User Kai Toellner, Birmingham University.

Friday 21 October 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Structure vs. Function: A quantitative analysis of chromosome architecture

User Luca Giorgetti - Friedrich Miescher Institute, Basel.

Friday 14 October 2016, 14:30-15:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Systemic inflammation negatively affects neurodegenerative disease: Priming of microglia and astrocytes at the interface of dementia and delirium"

Hosted by Lorinda Turner, Speaker: Colm Cunningham

User Dr Colm Cunningham, Trinity College Dublin.

Friday 14 October 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"IL-33 and Alzheimer’s disease"

Hosted by Gordon Dougan, Speaker: Foo (Eddy) Liew

User Foo (Eddy) Liew, University of Glasgow.

Friday 07 October 2016, 13:00-14:00

Cambridge Lymphoma Network (CaLy)

Voltage-gated proton channels influence BCR signalling in normal and malignant B cells

User Melania Capasso, Barts Cancer Institute.

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 09 September 2016, 12:00-13:00

Cambridge Lymphoma Network (CaLy)

Voltage-gated proton channels influence BCR signalling in normal and malignant B cells

User Melania Capasso, Barts Cancer Institute.

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 30 August 2016, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“A Force from within: Unexpected roles for innate immunity in intrinsic Th1 regulation"

Hosted by Ken Smith, Speaker: Claudia Kemper

User Claudia Kemper, King’s College London.

Friday 29 July 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Mechanisms of colon cancer initiation, progression and metastasis"

Host: Sakari Vanharanta (Hutchison/MRC talk)

User Joerg Huelsken, Associate Professor, Debiopharm Chair in Signal Transduction in Oncogenesis, EPFL, Lausanne.

Tuesday 05 July 2016, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Multiple levels of control for E4bp4/Nfil3 in NK cell development”

Hosted by Francesco Colucci, Speaker:Hugh Brady

User Hugh Brady, Imperial.

Friday 17 June 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Restriction of zoonotic viruses by bat Interferon-Induced Transmembrane Proteins

Hosted by Geoffrey Smith, Speaker: Camilla Benfield

User Camilla Benfield, RVC, London.

Friday 03 June 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Oh, to be seventeen again: IL-17 receptor signaling in fungal immunity and autoimmunity”

Hosted by Andrew McKenzie, Speaker: Sarah Gaffen

User Sarah Gaffen, University of Pittsburgh.

Friday 27 May 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"MicroRNA-mediated regulation of T follicular helper and Th17 cells"

Hosted by Michelle Linterman, Speaker:Dirk Baumjohann

User Dirk Baumjohann, Biomedical Centre, Munich.

Friday 20 May 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

T-cell differentiation in chronic infection – functional adaptation or exhaustion?

Hosted by Klaus Okkenhaug, Speaker: Dietmar Zehn

User Dietmar Zehn CHUV, Switzerland.

Friday 06 May 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Mechanisms of MYC-driven genome instability”

Host: Dr Anna Philpott

User Jean Gautier, Professor of Genetic and Development, Institute for Cancer Genetics, Columbia University, New York (USA).

Tuesday 03 May 2016, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

TGF-beta signaling in ILC3 prevents spontaneous microbiota-induced colorectal cancer

Hosted by Marc Veldhoen, Speaker: Julien Marie

User Julien Marie, CRCL, Lyon.

Friday 22 April 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Case Of The Missing Ribosomes: A Translational Mystery

Hosted by Paul Lehner, speaker Jon Yewdell

User Jon Yewdell, from NIH.

Monday 18 April 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Tracking down antigen specific T and B cells to dissect autoimmunity"

Speaker: Ludvig Sollid, Hosted by: Sarah Teichmann

User Ludvig Sollid,, University of Oslo..

Friday 11 March 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Single-cell analysis of hematopoietic stem cell identity and behaviour

User David Knapp -- Terry Fox Laboratory, Vancouver.

Tuesday 08 March 2016, 10:00-11:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Mechanisms and Pathways of microbe-host crosstalk in the GI tract"

Speaker: Simon Carding. Hosted by Marc Veldhoen

User Simon Carding, IFR Norwich.

Friday 26 February 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"The impact of immunogenetic variation on human disease”

Speaker: Mary Carrington, Hosted by: John Trowsdale

User Mary Carrington, NIH, US.

Friday 12 February 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"The human immune system is maintained in multiple stable equilibriums shaped by age and cohabitation"

Speaker: Michelle Linterman, Hosted by; Klaus Okkenhaug

User Michelle Linterman.

Friday 29 January 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Placing BETs on hold in AML

User Mark Dawson - Peter MacCallum Cancer Centre, Melbourne, Australia.

Wednesday 20 January 2016, 16:30-17:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Sub-clonal heterogeneity in chronic myeloid leukemia

User Mike Schmitt - Fred Hutchinson Cancer Research Centre, University of Washington.

Monday 18 January 2016, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Disturbed PI3K signalling as cause for primary immune deficiency disease"

Speaker: Sven Kracker, Hosted by: Sergey Nejentsev

User Sven Kracker.

Friday 15 January 2016, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Mobile elements, polydactyl proteins and the species-specificity of human biology”

Speaker: Didier Trono, Hosted by Yorgo Modis. Last talk of term

User Didier Trono, Ecole Polytechnique Fédérale de Lausanne, Switzerland.

Friday 04 December 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"A close up view on T cell mechanisms in autoimmunity : dissecting childhood arthritis"

Speaker: Lucy Wedderburn, Hosted By John Todd

User Lucy Wedderburn, UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust .

Thursday 19 November 2015, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Intrinsic and extrinsic determinants of pancreatic cancer stem cells

Host: Hutchison/MRC Research Centre Graduate Student Society

User Professor Christopher Heeschen, Centre Lead, Centre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, London.

Tuesday 17 November 2015, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Pathways that target PD-1 and the nuclear pore complex (NPC) in cancer immunotherapy"

Speaker: Christopher Rudd, Host: Martin Turner

User Christopher Rudd, Cambridge.

Friday 06 November 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Programming Humoural Immune Responses"

Speaker: Ed Clark, Hosted by Lalita Ramakrishnan

User Ed Clark, University of Washington.

Friday 23 October 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

‘A tale of cities; the differing challenges of antimicrobial resistance in Ho Chi Minh City and Kathmandu’

Speaker: Stephen Baker, Hosted by Ken Smith

User Stephen Baker.

Wednesday 14 October 2015, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Investigating the pathogenesis and developing new therapies for Respiratory Disease"

Speaker: Phil Hansbro, Hosted by Andrew McKenzie

User Phil Hansbro, The University of Newcastle, Australia.

Friday 09 October 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“In Situ Signatures of Apoptotic Cell Recognition”

Speaker: Julie Blander, Hosted By Clare Bryant

User Julie Blander, Icahn School of Medicine, NewYork.

Friday 25 September 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Taming the enemy within-host-epithelial interactions in the intestinal tract

Speaker: Philip Rosenstiel, Hosted by Arthur Kaser

User Philip Rosenstiel, University of Kiel.

Monday 14 September 2015, 14:00-15:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Dendritic cells in the initiation of immunity to infection and cancer"

Speaker: Caetano Reis e Sousa, Hosted By Yorgo Modis

User Caetano Reis e Sousa, Cancer Research UK London Research Institute.

Friday 11 September 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

‘Novel dual-action combination therapy enhances angiogenesis whilst reducing tumour growth and spread’

Hosts: Jacqui Shields/Sakari Vanharanta (Hutchison/MRC Research Centre)

User Professor Kairbaan Hodivala-Dilke, Professor of Angiogenesis, Deputy Institute Director QMUL .

Tuesday 07 July 2015, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The role of cystine-knot proteins in vertebrate immunity to Staphylococcus aureus

User Dr Andres Floto (University of Cambridge).

Friday 03 July 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Human and mouse mononuclear phagocyte networks: a tale of two species?

Muzlifah Haniffa, hosted by Menna Clatworthy

User Muzlifah Haniffa Newcastle.

Friday 19 June 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Insights into mammalian hematopoiesis from comparative functional genomic

Please note that this seminar is at 11am

User Prof. Ross Hardison (Penn State).

Wednesday 17 June 2015, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Making Hematopoietic Stem Cells: Backwards and Sideways

User Dr Derrick Rossi (Harvard, USA).

Friday 05 June 2015, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

'ECM remodelling during cancer progression'

Hosts: Sakari Vanharanta and Jacqui Shields (Hutch)

User Dr Janine Erler, Associate Professor - Biotech Research & Innovation Centre (BRIC),Copenhagen .

Tuesday 02 June 2015, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Identification of Regulatory Networks in HSCs and Their Immediate Progeny via Integrated Proteome, Transcriptome, and DNA Methylome Analysis

User Dr Nina Cabezas (DKFZ, Heidelberg).

Wednesday 20 May 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

DNA damage response: Mechanisms and relevance for cancer development and treatment

Hutchison/MRC Research Centre Seminar - Host: Hutchison/MRC Research Centre Graduate Student Society

User Professor Jiri Bartek, The Danish Cancer Society Research Center Genome Integrity Unit, Denmark.

Tuesday 19 May 2015, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Title to be confirmed

User Prof. Frederic Geissman, Kings College London.

Friday 08 May 2015, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tissue-resident memory T cells and role of antibodies in the LCMV model

User Hanspeter Pircher, Institute of Immunology, Freiburg.

Friday 08 May 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Metastatic Stem Cells, TGF-beta signalling and poor-prognosis in CRC

Hutchison/MRC Research Centre Seminar

User Dr Eduard Batlle (Group Leader, Institute for Research in Biomedicine, Barcelona).

Tuesday 05 May 2015, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immune evasion by the meningococcus: the competition hots up

Chris Tang, hosted by Felix Randow

User Chris Tang, Oxford.

Friday 24 April 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Innate Lymphoid Cells: New Players in Immune Defense and Tissue Homeostasis

James Di Santo, hosted by Martin Turner

User James Di Santo, Institut Pasteur.

Friday 10 April 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Aberrant chromatin programming in AML

User Prof. Constanze Bonifer, University of Birmingham.

Friday 20 March 2015, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mechanical forces in B cell activation

Pavel Tolar, hosted by John James

User Pavel Tolar, MRC National Institute for Medical Research, Mill Hill.

Friday 20 March 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Environmental sensing by blood cells

hosted by Marc Veldhoen

User Henrique Veiga-Fernandes, Instituto de Medicina Molecular, Lisbon..

Friday 06 March 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Systems Biology of Cancer

Host: Hutchison/MRC Research Centre Graduate Student Society

User Professor Jussi Taipale, Department of Biosciences and Nutrition, Karolinska Institute, Sweden .

Tuesday 03 March 2015, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Improved mismatched cell transplants for cancer immunotherapy

User Dr Francesco Colucci (University of Cambridge).

Friday 20 February 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Predictive Engineering of Cell Fate

Please note that this seminar is at 10am

User Prof. Peter Zandstra, University of Toronto.

Wednesday 11 February 2015, 10:00-11:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Novel functions for IgG in modulating immune highways and DC trafficking

Menna Clatworthy, hosted by Clare Bryant

User Dr Menna Clatworthy (University of Cambridge).

Friday 06 February 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

MYC Oncoproteins act as Epigenetic Modifiers

Hutchison/MRC Research Centre Seminar - Host by: Dr Anna Philpott

User Dr Frank Westermann, Research Group Neuroblastoma Genomics, DKFZ, Heidelberg.

Tuesday 03 February 2015, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Generating Immunity to an Immunosupressive Virus: The HIV Vaccine Conundrum

Jonathan Heeney, hosted by Gillian Griffiths

User Prof. Jonathan Heeney (University of Cambridge).

Friday 23 January 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Abnormalities in Plasma Cells in an Autoimmmune Disease Provide both a Window and a Key

David Tarlinton, hosted by Ken Smith

User David Tarlinton, WEHI, Melbourne .

Friday 09 January 2015, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mechanisms of immune-metabolic interaction in infection

Marc Dionne King's College London, Dptm of Immunobiology, hosted by Felix Randow

User Marc Dionne, King's College London.

Friday 12 December 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

In vivo function-based genomic approaches for cancer drug target discovery

Hutchison/MRC Research Centre Seminar

User Professor Daniel Peeper, Head, Division of Molecular Oncology, The Netherlands Cancer Institute.

Tuesday 02 December 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Lymphocyte population dynamics and genetic susceptibility to autoimmune disease

Rose Zamoyska,hosted by Maike de la Roche for the postdocs

User Rose Zamoyska, University of Edinburgh.

Friday 28 November 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cell fate in response to anti-mitotic chemotherapeutics

Hutchison/MRC Research Centre Seminar (please note unusual date)

User Professor Stephen Taylor, Faculty of Life Sciences, University of Manchester.

Wednesday 19 November 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mimicking of the process of human erythropoiesis using in vitro culture; studies on red blood cell membrane assembly and also use of 3D scaffolds

User Dr Ashley Toye, University of Bristol.

Friday 14 November 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Designing vaccines: genetics of T follicular helper cells (Tfh)

Shane Crotty, hosted by Michelle Linterman

User Shane Crotty, La Jolla Institute.

Friday 14 November 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Leukocyte migration and gradient sensing in vivo: lessons from zebrafish

Milka Sarris, hosted by Alex Betz

User Milka Sarris, Department of Physiology, Development and Neuroscience.

Friday 31 October 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Multiscale imaging of cell entry and innate immune recognition of enveloped RNA viruses

Yorgo Modis, chaired by Andrew McKenzie

User Yorgo Modis, Department of Medicine.

Friday 17 October 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Hematopoietic stem cell formation in the embryo

User Prof. Nancy Speck, University of Pennsylvania.

Thursday 16 October 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The role of stem cells in the pathogenesis of hepato-biliary cancers

Hutchison/MRC Research Centre Seminar

User Professor Nisar Malek, University of Tubingen, Germany.

Tuesday 07 October 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Understanding & Exploiting the NKT cell:CD1d System in Cancer and Other Diseases

Mark Exley, hosted by Arthur Kaser

User Mark Exley, Manchester Collaborative Centre for Inflammation Research (MCCIR).

Friday 03 October 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Clinical and Biological Impact of Flt3 mutations in Acute Leukaemia

User Dr Adam Mead, University of Oxford.

Friday 19 September 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Illuminating the microanatomical positioning and function of dendritic cells in vivo

Michael Gerner, hosted by Menna Clatworthy

User Michael Gerner, National Institute of Allergy and Infectious Disease, Bethesda.

Thursday 11 September 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Aurora A kinase and RPS14: new players in the myeloproliferative neoplasms

User Prof. John Crispino, Northwestern University, Chicago.

Monday 08 September 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting survival pathways in CML stem cell persistence and TKI-resistance

User Prof. Tessa Holyoake, University of Glasgow.

Monday 14 July 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Normal and leukaemic (AML) human stem/progenitor cells

User Prof. Paresh Vyas, WIMM, Oxford University.

Wednesday 02 July 2014, 16:15-17:15

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

PI3K in Immunity, Infection and Cancer

Klaus Okkenhaug

User Klaus Okkenhaug, Babraham Institute.

Friday 27 June 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Diversity of mouse B cell memory subsets

Claude-Agnès Reynaud, hosted by Cristina Rada

User Claude-Agnès Reynaud, INSERM.

Friday 13 June 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Regulation of Akt by the Sin1-mTOR complex in lymphocytes

User Prof. Bing Su (Department of Immunobiology at Yale, and Shanghai Institute of Immunology at Shanghai JiaoTong University School of Medicine).

Friday 06 June 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Undermining Myc: Mitochondria Hold the Key

Hutchison/MRC Research Centre Seminar

User Dr Daniel Murphy, Institute of Cancer Sciences, University of Glasgow.

Tuesday 03 June 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

HIV-1 Infection, Type-1 Interferon and Viral Restriction

Michael Malim, King's College London, hosted by Andrew Lever

User Michael Malim, King's College London.

Friday 30 May 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Models of the germinal centre reaction

Michael Meyer-Hermann, hosted by Michelle Linterman. Note change of venue!

User Michael Meyer-Hermann, Helmholtz Centre for Infection Research.

Friday 23 May 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

IL-22 and NRROS in host defense and inflammation

Wenjun Ouyang, hosted by Arthur Kaser

User Wenjun Ouyang, Genentech.

Friday 23 May 2014, 10:30-11:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting host endomembrane integrity during cellular invasion by bacterial pathogens and its impact on the immune response

Jost Enninga, hosted by Felix Randow

User Jost Enninga, Institut Pasteur.

Friday 16 May 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Title to be confirmed

Wenjun Ouyang, hosted by Arthur Kaser

User Wenjun Ouyang.

Wednesday 14 May 2014, 10:30-11:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Familial thrombocytopenias with predisposition to leukemia: RUNX1 targets

User Dr Hana Raslova, Institut Gustave Roussy, Paris.

Tuesday 13 May 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Spatio-temporal control of RhoGTPases and the cytoskeleton in invading cancer cells by integrins and endocytic trafficking

Hutchison/MRC Research Centre Seminar

User Dr Patrick Caswell, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester.

Tuesday 06 May 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Stromal cell regulation of lymph node structure and function

User Alice Denton, CRUK.

Friday 02 May 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Engaging mechanisms of negative B cell selection to overcome drug-resistance in leukaemia

User Prof. Markus Müschen, UCSF.

Tuesday 22 April 2014, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting bioenergetics in hypoxic and rapidly growing tumours

Hutchison/MRC Research Centre Seminar

User Dr Jacques Pouysseggur, Institute of Research on Cancer and Ageing (IRCAN), Nice, France.

Tuesday 08 April 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Neuroendocrine regulation of the bone marrow stem-cell niche

User Simón Méndez-Ferrer, CNIC, Madrid, Spain.

Friday 04 April 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Heterogeneity of hematopoietic stem and progenitor cell populations: implications for ageing and regeneration

User Claus Nerlov, University of Oxford.

Friday 21 March 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

HPV vaccines where to next?

Margaret Stanley

User Professor Margaret Stanley, Department of Pathology.

Friday 14 March 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Of mice and men and Tasmanian devils; assembling reference genomes from single cells.

User Dr Mark Hills, Terry Fox Lab, Vancouver, Canada.

Friday 14 March 2014, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Host-pathogen interactions: a biochemist's perspective

Hidde Ploegh, hosted by Gordon Dougan

User Hidde Ploegh, Whitehead Institute.

Thursday 13 March 2014, 14:30-15:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Notch and Wnt Signaling: From Hematopoeitic Stem Cells to Leukemia

User Anna Bigas. Cancer and Stem Cells Research Group. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM).

Friday 07 March 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cell death and autophagy in response to inhibition of glycolysis

Hutchison/MRC Research Centre Seminar

User Dr Cristina Muñoz Pinedo, IDIBELL, Barcelona, Spain.

Tuesday 04 March 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Prevention of immune pathology by specialized regulatory cell subsets

Luis Graca, hosted by Alex Betz

User Luis Graca, Universidade de Lisboa.

Friday 28 February 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Enhancing the CD8 T cell response by RAE-1 gamma expressed in a herpesvirus vector – not only NKG2D

Stipan Jonjic Rijeka, Croatia, hosted by Lars Dolken

User Stipan Jonjic, Rijeka, Croatia.

Friday 14 February 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

4D tracking of haematopoietic stem and progenitor cells in their bone marrow microenvironment

User Dr Cristina Lo Celso, Imperial College London.

Friday 07 February 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Translating Tumour Metabolism into New Diagnostics and Novel Anti-Cancer Therapeutics

Hutchison/MRC Research Centre Seminar

User Professor Michael Lisanti, Director of the Breakthrough Breast Cancer Research Unit, University of Manchester.

Tuesday 04 February 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

T cell migration in tumors: a role for matrix architecture

Emmanuel Donnadieu, hosted by Doug Fearon

User Emmanuel Donnadieu, INSERM, PAris.

Friday 31 January 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

SerenDRiPity: Translating DRiPs for T Cell Immunosurveillance of Tumors and Viruses

Jon Yewdell, hosted by Paul Lehner

User Jon Yewdell.

Friday 17 January 2014, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

User Bengt Hallberg (Umea University, Sweden).

Tuesday 07 January 2014, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Chasing metabolic alterations in cancer

Hutchison/MRC Research Centre Seminar

User Dr Arkaitz Carracedo, CIC bioGUNE, (Center for Cooperative Research in Biosciences), Derio, Spain.

Tuesday 07 January 2014, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The autophagy signaling network in the coordination of a cell's response

Hutchison/MRC Research Centre Seminar

User Prof Francesco Cecconi, University of Tor Vergata, Italy .

Tuesday 03 December 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cancer Epigenetics: Appreciating the beauty and complexity of a string of pearls

User Mark Dawson, University of Cambridge.

Friday 22 November 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Haematopoietic Stem Cells

User Prof. Connie Eaves, Terry Fox Laboratory, Vancouver.

Tuesday 12 November 2013, 12:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Emerging therapeutic strategies for treating the first molecular disease

User Prof. James Douglas Engel, University of Michigan Medical School, USA.

Friday 08 November 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Bone marrow environment and platelet production

User Assoc. Prof. Alessandra Balduini, University of Pavia Italy, and Tufts University USA.

Friday 18 October 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mutations in Epigenetic Modifiers in Myeloid Malignancies

User Dr Ross Levine, Memorial Sloan-Kettering Cancer Center, New York.

Tuesday 15 October 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Forward genetic screening using patient CML cells identifies IKAROS as a myeloid tumour suppressor

User Dr Philip Beer, Terry Fox Laboratory, Vancouver.

Monday 07 October 2013, 17:00-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Molecular and cellular basis of disease initiation in myeloproliferative neoplasms

User Prof. Radek Skoda, Head of the Department of Biomedicine, University Hospital, Basel.

Friday 20 September 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Look Beyond the Target: How Lessons from Chronic Myeloid Leukaemia Can Improve Cancer Targeted Therapies

User Assoc. Prof. Sin Tiong Ong, Duke-NUS Graduate Medical School Singapore & Duke University Medical Center.

Wednesday 18 September 2013, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Insights for the role of tumour-related inflammation and stem cells in Drosophila

Hutchison/MRC Research Centre Seminar

User Dr Marcos Vidal, Beatson Institute, Glasgow .

Tuesday 03 September 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetic modifiers and microenvironmental control of tumor invasiveness

Hutchison/MRC Research Centre Seminar- Please note unusual time and 1:00pm start

User Prof Douglas Hanahan, EPFL, Switzerland .

Tuesday 02 July 2013, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Control of cytokinesis and the dark side of actomyosin forces

Hutchison/MRC Research Centre Seminar

User Dr Mark Petronczki, London Research Institute.

Tuesday 04 June 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Macrophages Into Tumor Hypoxic Areas: Should I Stay Or Should I Go?

Hutchison/MRC Research Centre Seminar

User Dr Massimiliano Mazzone, VIB Vesalius Research Center, Belgium.

Tuesday 07 May 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Polycomb-mediated selfrenewal of young (and aged?) hematopoietic stem cells

User Gerald de Haan, Scientific Co-Director, European Research Institute for the Biology of Ageing.

Friday 03 May 2013, 11:00-12:00

CIMR Professional Development Seminars

Jobs in Science Seminars at the CIMR

User Various Speakers - panel discussion, see abstract.

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Friday 26 April 2013, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Telomeres and the challenges to chromosome integrity

Hutchison/MRC Research Centre Seminar

User Dr Julie Cooper, London Research Institute.

Tuesday 05 February 2013, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Innate immune signals in splenic and intestinal homeostasis"

User Andrea Cerutti. ICREA, Bacelona. Hosted by Michael Neuberger.

Friday 07 December 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Localisation-based feedback controls during mitosis and the maintenance of chromosomal stability

Hutchison/MRC Research Centre Seminar

User Dr Adrian Saurin, University Medical Center Utrecht, The Netherlands.

Tuesday 04 December 2012, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Epigenetic reprogramming in mammalian development

User Wolf Reik.

Friday 30 November 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Targeting T cells for immune staging and intervention in type 1 diabetes"

User Dr Roberto Mallone, Hôtel Dieu Hospital. Hosted by John Todd.

Friday 30 November 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Global Progress in TB Vaccine Development"

User Professor Helen McShane, University of Oxford. Hosted by Andres Floto.

Friday 23 November 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Preclinical and Clinical Studies of Immunotherapy in Type 1 Diabetes"

User Dr Frank Wadron-Lynch, JDRF/WT Diabetes & Inflammation Lab, CIMR. Hosted by Linda Wicker.

Friday 16 November 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"ADARs and innate immunity"

User Mary O'Connell, MRC, Human Genetics Unit, Edinburgh. Hosted by Felix Randow.

Friday 09 November 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Signalling Networks in Cell Proliferation and Fate Control

Hutchison/MRC Research Centre Seminar

User Professor Sibylle Mittnacht, UCL Cancer Institute.

Tuesday 06 November 2012, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"The FAP+ Stromal Cell and a Hierarchy of Tumour Immune Suppression."

User Doug Fearon, CRUK. Hosted by John Trowsdale.

Friday 02 November 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Aging of Hematopoietic Stem Cells

User David Bryder, Lund University.

Tuesday 30 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Manipulating the dynamics of ubiquitin and histones in cells to create new antigens for MHC class I antigen presentation”

User Jacques Neefjes, The Netherlands Cancer Institute, Amsterdam. Hosted by Paul Lehner.

Friday 26 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genome-wide mapping of DNA rearrangements in single cells using DNA template strand sequencing

User Peter Lansdorp, European Research Institute on the Biology of Ageing, University of Groningen.

Friday 19 October 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Principles of dynamic gene regulation in mammals"

User D. Ido Amit, Weizman Institute, Israel. Hosted by Sarah Teichman.

Friday 19 October 2012, 14:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tet proteins and methylcytosine oxidation

User Anjana Rao, La Jolla Institute for Allergy and Immunology.

Monday 15 October 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"High resolution gene expression profiling of TNA synthesis, processing and decay"

User Lars Dolken, Dept of Medicine. Hosted by Paul Lyons.

Friday 12 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Adventures in Viral Immunology: Translating DRiPs

User Professor Jon Yewdell, NIAID. Hosted by Paul Lehner.

Monday 08 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

New insights into bone marrow biology

User Professor Sara Rankin, Imperial College London. Hosted by Edwin Chilvers.

Friday 05 October 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

" Not all Foxp3+ Regulatory T cells cells are made equal- miRNA-mediated regulation of specialisation"

User Dr Mark Wilson, NIMR. Hosted by Michelle Linterman.

Friday 28 September 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

IFN-inducible GTPases and the art of self defense

User John MacMicking, Yale University School of Medicine. Hosted by Felix Randow.

Friday 21 September 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Microbial versus metabolic inflammation: fine-tuning inflammasomes via a GTPase

User Dr Avinash Shenoy, Yale School of Medicine. Hosted by Ken Smith.

Friday 14 September 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Microbial versus Metabolic Inflammation: Fine-tuning Inflammasomes via a GTPase"

User Dr Avinash Shenoy, Yale School of Medicine. Host tbc.

Monday 30 July 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

CD45 and TIM-1: unique targets for induction of regulatory T and B cells in transplant tolerance"

User Professor David Rothstein, University of Pittsburgh. Hosted by Chris Rudd.

Friday 13 July 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Regulating T cells in autoimmune and allergic disease"

User Professor Stephen M Anderton, MRC Centre for Inflammation Research, University of Edinburgh. Hosted by Andrew McKenzie.

Friday 06 July 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Fueling the fires within: TNF-family receptors in autoimmunity and autoinflammation

User Dr Richard Siegel, National Institute of Arthritis and Musculoskeletal & Skin Diseases, NIH. Hosted by Menna Clatworthy.

Friday 29 June 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Cell Entry and Innate Immune Recognition of enveloped RNA Viruses”

User Dr Yorgo Modis, Yale University. Hosted by Ken Smith.

Friday 22 June 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“Accelerated vaccine and immunotherapy discovery and development: case studies in infectious diseases and cancer"

User Dr Mark Poznansky, Massachusetts General Hospital. Hosted by Andrew Lever.

Monday 18 June 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Epithelial regulation of intestinal inflammation"

User Professor Manolis Pasparakis, CECAD, Cologne. Hosted by Arthur Kaser.

Friday 15 June 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Taking Advantage: Exploring Darwinian Selection in the Germinal Center"

User Dr Mark Shlomchik, Yale School of Medicine. Hosted by Ken Smith.

Tuesday 12 June 2012, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Bad blood between the ribosomal subunits"

User Professor Alan Warren, University Department of Haematology and MRC-LMB. Hosted by Michael Neuberger.

Friday 08 June 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"The cancer macroenvironment modulates adaptive immunity against cancer"

User Dr Vincenzo Bronte, Instituto Oncologico Veneto, Padua, Italy. Hosted by Doug Fearon.

Friday 01 June 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Mesenchymal and haemopoietic stroma: a crucial liaison"

User Professor Francesco Dazzi, Chair in Stem Cell Biology and Head of Stem Cell Biology, Dept of Medicine, Imperial College London. Hosted by John Todd.

Friday 25 May 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Enhancing immune responses by targeting vaccine antigens to Clec9A on dendritic cells"

User Professor Ken Shortman, The Walter and Eliza Hall Institute, Australia. Host tbc.

Monday 21 May 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Spatio-temporal regulation of antigen presentation and cell migration"

User Dr Ana-Maria Lennon-Duménil, Institute Curie, Paris. Hosted by Marion Espeli.

Friday 18 May 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immune cell transdifferentiation

User Thomas Graf, Centre for Genomic Regulation (Barcelona).

Friday 11 May 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"The BLIMP-1 regulatory network and models of plasma cell differentiation"

User Dr Gina Doody, Leeds Institute of Molecular Medicine. Hosted by Martin Turner.

Friday 11 May 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transcriptional profiling host responses in Infectious diseases: From HIV infection of macrophages to the tuberculin skin test

User Dr Mahdad Noursadeghi, UCL. Hosted by Andres Floto.

Friday 04 May 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Germinal center selection and the development of memory B and plasma cells"

User Dr Mark Shlomchik, Yale School of Medicine. Hosted by Michael Neuberger.

Wednesday 25 April 2012, 16:30-17:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Control of intercellular signalling by rhomboids and their relatives"

User Dr Matthew Freeman, MRC Laboratory of Molecular Biology. Hosted by Paul Lehner.

Friday 20 April 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"Into thin air: regulation of inflammatory gene expression by hypoxia"

User Professor Cormac Taylor, UCD Conway Institute. Hosted by Edwin Chilvers.

Friday 13 April 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

“CD45 and TIM-1: unique targets for induction of regulatory T and B cells in transplant tolerance"

User Professor David Rothstein, University of Pittsburgh. Hosted by Chris Rudd.

Friday 13 April 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Always on guard: p53 dynamics in single living cells

Hutchison/MRC Research Centre Seminar

User Dr Alexander Loewer, Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Germany.

Tuesday 03 April 2012, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Malaria and Salmonella: tolerance versus resistance

User Professor Eleanor Riley London School of Hygiene & Tropical Medicine. Hosted by John Trowsdale..

Friday 30 March 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

"The earliest events in T cell receptor activation"

User Professor Kai Wucherpfennig, Dana Farber Cancer Institute, Harvard. Hosted by Ken Smith.

Monday 26 March 2012, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Local interactions and genome-wide co-associations of proto-oncogenes: the short and the long of it.

User Cameron Osborne, Babraham Institute.

Friday 23 March 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Basophils in immune responses against helminths and allergens

User Professor David Voehringer Friedrich Alexander University of Erlangen‐Nurnberg, Germany. Hosted by Andrew McKenzie..

Friday 23 March 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Novel connections between anti-viral innate immunity and metabolism: A Systems Biology Approach

User Dr Hwjin Kim, Department of Genetics, Harvard Medical School. Hosted by Paul Lehner.

Tuesday 20 March 2012, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Structural determinants underlying ubiquitin chain linkage specificity in NF-kB signalling

User Dr Yogesh Kaluthu MRC LMB, Cambridge, hosted by Paul Lehner..

Friday 16 March 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mechanisms of innate and adaptive T cell help to B cells during infection and immunity

User Dr Irah King, Trudeau Institute. Hosted by Paul Lehner.

Thursday 15 March 2012, 14:30-15:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monocytes, macrophages & DCs development pathways that specify functions

User Professor Frederic Geissmann King’s College London. Hosted by Hill Gaston..

Friday 09 March 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The thymus: 500 million years in the making

User Professor Thomas Boehm Max Planck Institute of Immunobiology and Epigenetics, Freiberg, Germany. Hosted by Ken Smith..

Tuesday 06 March 2012, 16:15-17:15

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Differentiation of plasma cells, and selection in the germinal centre.

User Dr Kai Michael Toellner University of Birmingham, hosted by Elena Vigorito..

Friday 02 March 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Development of Foxp3+ regulatory T cell: epigenetics and more…

User Professor Jochen Huehn Helmholtz Centre for Infection Research, Germany. Hosted by Alex Betz..

Friday 24 February 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Vitamin D and tuberculosis

User Dr Adrian Martineau Queen Mary University of London, Barts and The London School of Medicine and Dentistry. Hosted by John Todd..

Friday 17 February 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immunity to Streptococcus pneumoniae

User Dr Jerry Brown University College London. Hosted by Andres Floto..

Friday 10 February 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Molecular mechanisms of human T helper cell differentiation to functionally distinct subsets

User Professor Riitta Lahesmaa Turku Centre for Biotechnology, Finland. Hosted by Sarah Teichmann..

Wednesday 08 February 2012, 11:00-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transcriptional control of EMT and malignant tumor progression

Hutchison/MRC Research Centre Seminar

User Prof Gerhard Christofori, University of Basel, Switzerland.

Tuesday 07 February 2012, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting B cells in Cardiovascular Diseases

User Professor Ziad Mallat, Department of Medicine, University of Cambridge.

Friday 03 February 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How do enhancers and promoters interact and what are the consequences ?

User Doug Higgs, Weatherall Institute, Oxford,.

Friday 27 January 2012, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The αβTCR uses an antibody‐like strategy to engage MHC‐peptide

User Professor Julian Dyson Dept of Medicine, Imperial College, London. Hosted by Linda Wicker..

Friday 27 January 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transcriptional and chromatin regulation of T helper cell differentiation

First talk of Lent Term

User Dr Richard Jenner, University College London, hosted by Sarah Teichmann.

Friday 20 January 2012, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Title to be confirmed

Last talk of term. Note change of speaker

User Dr Richard Blumberg, Harvard School of Medicine, hosted by Students and Postdocs, Smith lab.

Friday 09 December 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Commitment and plasticity in the B cell lineage

User Research Institute of Molecular Pathology Vienna, Austria.

Tuesday 06 December 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Compartments and continua of the immune responses to commensal intestinal microbes

User Professor Andrew MacPherson, University of Bern, Switzerland, hosted by Arthur Kaser.

Friday 02 December 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

MHC-determined resistance to a herpes virus: some new pictures of peptide motifs for class I and TAP molecules

User Professor Jim Kaufman, Dept of Pathology, University of Cambridge, hosted by Paul Lehner.

Friday 25 November 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Pattern Recognition Receptors: therapeutic targets for allergic as well as infectious disease?

User Dr Clare Bryant, Dept of Clinical Veterinary Medicine, University of Cambridge, hosted by Edwin Chilvers.

Friday 18 November 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Retinoic acid: An immune morphogen?

User Dr Randy Noelle, Dartmouth University and King's College, London, hosted by Chris Rudd.

Friday 11 November 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Long non-coding and extracoding RNAs in normal haematopoiesis and leukemia

User Dan Tenen, Cancer Science Institute of Singapore and Harvard Medical School.

Monday 07 November 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Chaperoning antibody diversification

User Dr Javier di Noia, Insitut de Recherches Cliniques de Montreal, hosted by Michael Neuberger.

Friday 04 November 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

HIV-related mortality past and present

User Professor Sebastian Lucas, King's College London School of Medicine, hosted by Leo James.

Friday 21 October 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Hedgehog signalling in T-cell differentiation

User Dr Tessa Crompton, Institute for Child Health, University College London, hosted by Gillian Griffiths.

Friday 14 October 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Control of inflammation by natural and synthetic histone mimics

Note unusual time

User Professor Sasha Tarakhovsky, The Rockefeller University, New York, hosted by Ken Smith.

Thursday 13 October 2011, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Bridging the Gap: Computational Biology and Trafficking of MHC Class I

User Professor Sebastian Springer, Jacobs University, Bremen, hosted by John Trowsdale.

Friday 07 October 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Journey to the Centre of Translation: In Situ Visualisation and Characterisation of Compartmentalised Protein Synthesis in Cells and Tissues

User Alexandre David, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, USA, hosted by Paul Lehner/Ken Smith.

Friday 30 September 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Chromatin, chromosome and nuclear dynamics, links to genome function

User Peter Fraser, Babraham Institute.

Friday 23 September 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Multiplexed assays for studying immunologic diseases

User Professor PJ Utz, Stanford School of Medicine, California, hosted by Paul Lyons.

Friday 23 September 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genome-wide DNA methylation analysis in stem cells and cancer

User Christoph Bock, Broad Institute.

Friday 16 September 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Innate Lymphoid Cells: An Emerging Family of Immune Effectors

User Professor Jim di Santo, Institut Pasteur, Paris, France, hosted by Francesco Colucci.

Friday 16 September 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Approaches to and biomarkers of transplantation tolerance

Note unusual time

User Professor Robert Lechler, King's College, London, hosted by Ken Smith.

Wednesday 14 September 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Salmonella diarrhea - from molecular analysis to the real infection

User Professor Wolf-Dietrich Hardt, Institute of Microbiology, Zurich, hosted by Felix Randow.

Friday 09 September 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Molecular Mechanisms in cytotoxicity by SLAM family receptors

User Dr Marion Brown, Dunn School of Pathology, Oxford, hosted by Gillian Griffiths.

Friday 02 September 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Regulation of immune responses to pancreas-expressed antigens: role of CTLA-4

User Dr Lucy Walker, University of Birmingham, hosted by John Todd.

Friday 22 July 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

NOD2-dependent autophagy and Crohn's disease

User Dr Alison Simmons, Nuffield Dept of Clinical Medicine, University of Oxford, hosted by Arthur Kaser.

Friday 15 July 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Retinoic acid: An immune morphogen?

User Randy Noelle, Dartmouth University and King's College London hosted by Chris Rudd.

Friday 08 July 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Control of immune homeostasis by regulatory T cells

Special Seminar: Note unusual time

User Dr Sasha Rudensky, The Memorial Sloan-Kettering Cancer Center New York, hosted by Paul Lehner.

Thursday 07 July 2011, 12:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Development of hematopoietic stem cells: an outline of the final scenario

User Shin-Ichi Nishikawa, Riken CDB, Kobe.

Wednesday 06 July 2011, 10:00-11:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Imaging neutrophilic inflammation in vivo: what we can learn from studies in zebrafish

User Stephen Renshaw, University of Sheffield, hosted by Edwin Chilvers.

Friday 01 July 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Between tolerance and vigilance - host-microbial homeostasis at the intestinal epithelium

User Professor Mathias Hornef, Hannover Medical School hosted by Felix Randow.

Friday 24 June 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Why do we need a Fanconi Anaemia DNA repair pathway?

User KJ Patel, MRC LMB, Cambridge.

Friday 17 June 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immunglobulin enhancers and AID targeting during class switch recombination

User Dr Amine Khamlichi, University of Toulouse, France hosted by Michael Neuberger.

Friday 17 June 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Making and br(e)aking CD effector/memory responses

User Professor Peter Lane, University of Birmingham, hosted by Students/Post docs.

Friday 10 June 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetics and therapy of AML: role of mutations in the epigenetic machinery

User Ross Levine, Memorial Sloan-Kettering, New York.

Thursday 09 June 2011, 13:30-14:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Autophagy in the hematopoitic system

Special Seminar: Note unusual time

User Professor Katia Simon, Weatherall Institute of Molecular Medicine, Oxford University, hosted by Andres Floto.

Tuesday 07 June 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

War and peace at the mucosal interface in the gut

User Claudio Nicoletti, Institute of Food Research, Norwich hosted by Hill Gaston/Jane Goodall.

Friday 03 June 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genes, cells and pathways - Post GWAS

Special Seminar: Note unusual time

User Ramnik Xavier, Harvard Medical School Broad Institute of MIT and Harvard, hosted by John Todd.

Wednesday 01 June 2011, 10:00-11:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mapping the functional interaction network of mammalian ER-associated degradation

User John Christianson, Ludwig Institute for Cancer Research, Oxford hosted by Paul Lehner.

Friday 27 May 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Gut, germs and genes: the role of the microflora in intestinal oncogenesis

Special Seminar: Note unusual time

User Eyal Raz, University of California San Diego, hosted by Arthur Kaser.

Wednesday 25 May 2011, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Essential role of lymph node stroma in orchestrating efficient immune responses

User Dr Mark Coles, University of York, hosted by Andrew McKenzie.

Friday 20 May 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The development of HSCs: endothelial to hematopoietic transition

User Elaine Dzierzak, Erasmus MC, Rotterdam.

Friday 13 May 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immune modulation via C-type lectins

User Dr Veronique Braud, Institut de Pharmacologie Moleculaire et Cellulaire, Valbonne, France, hosted by Francesco Colucci.

Friday 13 May 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Studying precancerous stem cells in mouse models of T cell leukaemia

User Matthew McCormack, WEHI, Melbourne.

Monday 18 April 2011, 10:30-11:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Harnessing cytomegaloviral immune evasion for vaccine development

User Klaus Frueh, Oregon Health & Science University hosted by Paul Lehner.

Friday 15 April 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Local development of Follicular Helper T cells

User Nicolas Fazilleau, Purpan Hospital, Toulouse hosted by Students/Post docs.

Friday 08 April 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Environment specific control of immune reactivity: lessons from studying mucosal immune responses in man

User Professor Stefan Meuer, Ruprecht-Karls-Universität Heidelberg hosted by Chris Rudd.

Friday 01 April 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How we achieve tolerance for our mothers: Evidence for a layered Immune System in Humans

User Dr Jeff Mold, Karolinska Institute, Stockholm, Sweden hosted by Alex Betz.

Friday 25 March 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Pathways of inflammation and tissue remodelling in immune-mediated inflammatory diseases: lessons from human arthritis

User Dr Dominique Baeten, University of Amsterdam hosted by Hill Gaston.

Friday 18 March 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Title to be confirmed

User Speaker to be confirmed.

Monday 14 March 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Investigations to determine causal molecules in Crohn’s disease and ulcerative colitis

User Anthony Segal, Director, Centre for Molecular Medicine, UCL hosted by John Todd.

Friday 11 March 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The generation of antibody-based diagnostics and therapeutics for emerging infectious diseases

PLEASE NOTE THAT THIS SEMINAR IS TAKING PLACE ON TUESDAY

User Dr Paul MacAry, National University of Singapore hosted by Ken Smith.

Tuesday 08 March 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Establishing the molecular basis of the persistence of immunological memory

User David Tarlinton, WEHI, Melbourne hosted by Ken Smith.

Friday 04 March 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetic complexity in MPN and MDS/MPN

User Nick Cross, Univeristy of Southampton.

Friday 25 February 2011, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Early events in B cell activation: from single molecules to living tissue

User Facundo Batista, CRUK.

Friday 25 February 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Nuocytes: new insights in type-2 immunity

User Andrew McKenzie, MRC Laboratory of Molecular Biology hosted by Ken Smith.

Friday 18 February 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Intracellular Immunity: neutralizing viruses inside infected cells

User Dr Leo James ( MRC-LMB, Cambridge) hosted by John Trowsdale.

Friday 11 February 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Understanding natural acquired malaria immunity or what malaria understands about the immune system that immunologists don’t

PLEASE NOTE THAT THIS SEMINAR IS TAKING PLACE ON WEDNESDAY AT THE LATER TIME OF 2.30 - 3.30 PM

User Susan Pierce, Chief, Laboratory of Immunogenetics, NIAID, NIH, Rockville hosted by Ken Smith.

Wednesday 09 February 2011, 14:30-15:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Paternal MHC linked to uterine vascular remodelling and feto-placental growth

User Francesco Colucci, Centre for Trophoblast Research, University of Cambridge hosted by Linda Wicker.

Friday 04 February 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The lectin activation pathway of complement and the mysteries of inflammatory pathologies

User Professor Wilhelm Schwaeble, University of Leicester hosted by Doug Fearon.

Friday 28 January 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Th2 response induction by dendritic cells: lessons from pathogens

User Dr Andrew S MacDonald, Institute of Immunology and Infection Research, University of Edinburgh hosted by Andrew McKenzie.

Friday 21 January 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

A quantitative view of gene expression levels in T helper cells

User Dr Sarah Teichmann, MRC Programme Leader, Computational Genomics, MRC Laboratory of Molecular Biology hosted by Doug Fearon.

Friday 14 January 2011, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

ZnT8- a major autoantigen in human type 1 diabetes

User Howard Davidson, University of Colorado, Denver - Hosted by Paul Luzio.

Friday 17 December 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Post-transcriptional control of inflammation

User Paul Anderson, Brigham and Women's Hospital, Harvard Medical School - Hosted by Chris Rudd.

Friday 10 December 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

B lymphocyte regulation of inflammation and autoimmunity

JOINT IMMUNOLOGY IN PATHOLOGY & IMMUNOLOGY & MEDICINE SEMINAR - Speak to Professor Tedder after his seminar in the Level 7 Lounge with a coffee and a cake.

User Professor Tom Tedder, Duke University, USA - Hosted by Chris Rudd.

Wednesday 08 December 2010, 12:00-13:00

Immunology in Pathology

B lymphocyte regulation of inflammation and autoimmunity

Host: Chris Rudd, cer51@cam.ac.uk

User Professor Tom Tedder, Duke University.

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Wednesday 08 December 2010, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Clonotypic determinants of biological outcome: the importance of the naive T cell repertoire

User David Price, University of Cardiff - Hosted by Paul Lehner.

Friday 03 December 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transcriptional control of CD4/CD8 lineage decision during T cell development

User Wilfried Ellmeier, Medical University of Vienna - Hosted by Paul Lyons.

Friday 26 November 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

T follicular helper cells in protective immunity and autoimmunity.

PLEASE NOTE THAT THIS SEMINAR IS ON MONDAY AT 4.00 PM

User Carola Vinuesa, John Curtin School of Medical Research, Australian National University.

Monday 22 November 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Macrophage lectins and the antifungal response

User Philip Taylor, Dept of Infection, Immunity and Biochemistry, Cardiff - Hosted by Edwin Chilvers.

Friday 19 November 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Restriction of the felid retroviruses by BST2/tetherin

User Brian Willett, Institute of Infection, Immunity and Inflammation, Glasgow.

Friday 12 November 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Insights into the molecular basis of myelodysplastic syndrome

User Ben Ebert, Department of Medicine, Harvard Medical School.

Thursday 11 November 2010, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The septin cage: a novel assembly of host defense against cytosolic bacteria

User Serge Mostowy, Institut Pasteur, Paris - Hosted by Felix Randow.

Friday 05 November 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Epigenetics - New regulators of gene expression

User Steffen Gay, University Hospital, Zürich - Hosted by Hill Gaston.

Friday 29 October 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Two lessons from bench to bedside: Why do we need to feed our gut with IL10 and a surprising role of antibodies in the innate immune defence to Candida

User Bodo Grimbacher, UCL , Research Department of Immunology - Hosted by Ken Smith.

Friday 22 October 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Leukemic stem cells - a challenging adversary

User Keith Humphries, Terry Fox Laboratories, Vancouver, Canada.

Friday 15 October 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The critical functions of transcription factor Bcl11b in T cell development and maintenance of T cell identity

If you would like to talk with Pentao Liu before his seminar on Friday he will be available from 12.00 - 1.00 pm in the Level 7 Cafeteria. He will also be available after his seminar in the cafeteria from 2.00 - 3.00 pm

User Pentao Liu, Sanger Institute, Wellcome Trust Genome Campus, Hinxton - Hosted by Francesco Colucci.

Friday 15 October 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Multiple sclerosis: functional genetics

User Lars Fugger, Weatherall Institute of Molecular Medicine, University of Oxford - Hosted by John Todd.

Friday 08 October 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Blimp1 and IRF4 are jointly required for the differentiation of effector regulatory T cells

User Axel Kallies, The Walter and Eliza Hall Institute of Medical Research, Melbourne - Hosted by Ken Smith.

Friday 01 October 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tissue stem cell fate: lessons from lineage tracing and statistical physics

User Ben Simons, Cavendish Laboratory, University of Cambridge - Hosted by Patrick Sissons, Regius Professor of Physic.

Friday 17 September 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Alpha beta and gamma delta T cell recognition of transformed self via novel antigenic targets

User Ben Willcox, CRUK Cancer Centre, University of Birmingham - Hosted by John Trowsdale.

Friday 10 September 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Initiation and progression of leukemia – lessons from Down Syndrome

User Shai Izraeli, Tel Aviv University, Israel.

Thursday 09 September 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Modeling APL pathogenesis through therapy response

User Hugues de Thé MD, PhD, University of Paris, Head, INSERM/CNRS/University Paris 7.

Thursday 29 July 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Genetics of a transmissible facial tumour in the Tasmanian devil (2 talks, same title)

Host - Marion Espeli

User Elizabeth Murchison and Hannah Siddle.

Friday 02 July 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Understanding T cell: B cell interactions through studies of X-linked lymphoproliferative syndrome

Please note this talk will be on a MONDAY. Hosted by Gillian Griffiths

User Pam Schwartzberg, National Human Genome Research Institute, Genetic Disease Research Branch, Bethesda.

Monday 28 June 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Role of Cytomegalovirus miRNAs in Virus Pathogenicity

PLEASE NOTE CHANGE OF DAY - Host - Martin Turner

User Lars Dolken, Max von Pettenkofer-Institute, Munich.

Monday 21 June 2010, 14:00-15:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Forward and reverse genetics of memory T lymphocytes

Hosted by Alex Betz

User Philip Ashton-Richardt.

Friday 18 June 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

T cell turnover in vivo using stable isotope labelling

Please note change of day - WEDNESDAY. Hosted by John Todd

User Kristin Ladell - National Institute of Health, Bethesday/University of Cardiff.

Wednesday 16 June 2010, 12:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

High definition immune profiling of antigen-specific T cells: implications for disease pathogenesis and vaccine design

Please note change of day - WEDNESDAY. Hosted by John Todd

User David Price National Institute of Health/Cardiff University.

Wednesday 16 June 2010, 12:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Interactions between a cell signalling pathway and a haematopoietic transcriptional network

User John Pimanda, University of New South Wales.

Friday 11 June 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Unexpected coding capacities in the influenza A virus genome

Host - Ken Smith

User Paul Digard, Department of Pathology.

Friday 11 June 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

In vivo imaging of haematopoietic stem and progenitor cells interacting with their niche(s)

User Cristina Lo Celso, Imperial College, London.

Friday 04 June 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How cells defend their cytosol against baterial attack

Hosted by Andrew McKenzie

User Felix Randow - LMB-MRC, Cambridge.

Friday 04 June 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Imaging of T cell migration in slices of murine lymph nodes and human tumors

Host - Chris Rudd

User Emmanuel Donnadieu - Department de Biologie, Cellulaire, Institut Cochin, Paris.

Friday 28 May 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Antibody-mediated graft rejection - a cytotopic therapeutic approach

Host Douglas Fearon

User Richard Smith.

Friday 21 May 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Host response to micobacterium abscessus

Host - Andres Floto

User Dr Jean-Louis Herrmann, Hopital Saint-Louis, Paris.

Tuesday 18 May 2010, 17:00-18:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

T cell signals that control motility and interactions with dendritic cells in lymph nodes

Host - Gillian Griffiths

User Prof. Chris Rudd, Department of Pathology, University of Cambridge.

Friday 14 May 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How do maternal NK cells affect reproductive success?

Host - Francesco Colucci

User Ashley Moffett, Department of Pathology, University of Cambridge.

Friday 07 May 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Microenvironmental effects of apoptosis in vivo and in vitro: uncovering a "new biology" of cell death?

Host - Edwin Chilvers

User Chris Gregory - University of Edinburgh, MRC Centre for Inflammation Research.

Friday 30 April 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Role of P13P during initiation of autophagy

Hosted by Felix Randow

User Nicholas Ktistakis, Babraham Institute, Babraham.

Friday 23 April 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4

Host - Chris Rudd

User Michelle Janas, Babraham Institute, Babraham, Cambridge.

Friday 16 April 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Dengue virus, innate immunity and disease control

Host Leo James

User Michael Jacobs - University College London, Infection and Immunity.

Friday 09 April 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Functional genomic landscapes by gene disruption and parallel sequencing connect genes to human disease

Hosted by Paul Lehner

User Jan Carette - Whitehead Institute, MIT, Boston.

Friday 26 March 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Making HIV epitopes - antigen processing and CTL responses

Hosted by Paul Lyons

User Astrid Iversen - Weatherall Instittue of Molecular Medicine, Oxford.

Friday 19 March 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Calcium-dependent T-cell activation

Host - Gillian Griffiths - Please note change of day and time.

User Markus Hoth, University of Saarland, Germany.

Tuesday 16 March 2010, 12:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Investigating the lymphoid stress-surveillance response

Host - Douglas Fearon

User Adrian Hayday - Division of Immunology, Infection & Inflammatory Diseases, Kings College, London.

Friday 12 March 2010, 12:30-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Human cytomegalovirus and its obsession with Natural Killer cells

Host - John Trowsdale

User Gavin Wilkinson, Medical Microbiology, University of Cardiff.

Friday 05 March 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immunotherapy of established disease caused by high risk Human Papilloma Virus

Host - Douglas Fearon

User Cornelis Melief, Leiden University Medical Center, Dept. Immunohematology and Bloodtransfusion.

Friday 26 February 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Generation of stable monoclonal antibody-producing human memory B cells by genetic programming

Host - Students. Please note change of day and time - Monday at 11.30

User Hergen Spits - Academic Medical Centre, University of Amsterdam, The Netherlands.

Monday 22 February 2010, 11:30-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

E4bp4 and NK cells

Host - Andrew McKenzie

User Hugh Brady, Division of Cell and Molecular Biology, Imperial College.

Friday 19 February 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

MicroRNA regulation in B cell fate

Host - Michael Neuberger

User Almudena Ramiro - CNIIO Spanish National Cancer Research Centre, Madrid.

Friday 05 February 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Wellcome Trust Thailand Major Overseas Programme - current research and future challanges

Hosted by Patrick Sisssons. Please note change of day and time

User Nick Day, Professor of Tropical Medicine, Director of the Mahidol Oxford Clinical Research Unit, Thairland.

Thursday 04 February 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Individual and Allele specific chromatin: discovery and consequences

Hosted by John Todd.

User Ewan Birney - European Molecular Biology Laboratory, European Bioinformatics Institute.

Friday 29 January 2010, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Invariant NKT cell receptors: innate-type recognition with an adaptive gear

Host - Hill Gaston

User Stephan Gadola, Division of Infection, University of Southampton.

Friday 29 January 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Asymmetric Immune control by Foxp3+ regulatory T cells

Hosted by The Cambridge Immunology Post-doc Society

User Adrian Liston - Autoimmune Genetics Laboratory VIB/K.U. Leuven, Belgium.

Friday 22 January 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How can the immune system be regulated?

Host - Gillian Griffiths. Please note change of day and time TUESDAY 12.30

User Herman Waldmann, Sir William Dunn School of Pathology, University of Oxford.

Tuesday 19 January 2010, 12:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Probing the Unfolded Protein Response with small molecules

Host - Paul Lehner

User David Ron - Institute of Metabolic Sciences, University of Cambridge.

Friday 15 January 2010, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Endoplasmic Reticulum Stress and Intestinal Inflammation

Host Ken Smith - Please note change of day and time - TUESDAY 4pm. Part of the Cambridge Biomedical Research Centre Lecture Series 2010

User Arthur Kaser - Innsbruck Medical University.

Tuesday 12 January 2010, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Innate regulation of dendritic cell function

Host - John Todd

User Caetano Reis e Sousa, Cancer Research UK, Univeristy College, London.

Friday 04 December 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Novel crosstalk between the ER stress and TLR signaling pathway

Host - Hill Gaston

User Jane Goodall, Dept of Medicine, University of Cambridge.

Friday 27 November 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Commonalities in the genetic control of liver disease induced upon bacterial infection and type 1 diabetes

Host - Linda Wicker

User Jochen Mattner, Cincinnati Children's Hosp. Medical Center, Cincinnati, Ohio.

Friday 20 November 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Neutrophil extracellular traps

Host - Felix Randow

User Arturo Zychlinsky, MPI for Infection biology, Berlin.

Friday 13 November 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Plastic T cells: from mechanism to prediction in childhood arthritis

Host - Hill Gaston

User Lucy Wedderburn - University College London.

Friday 06 November 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Chronic antigenic stimulation and the human immune system : lessons from herpesviruses and cancer

Host - Douglas Fearon

User Paul Moss, University of Birmingham.

Friday 30 October 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

PI3K in lymphocyte development and activation

Host Gillian Griffiths

User Klaus Okkenhaug, Babraham Institute, Babraham, Cambridge.

Friday 23 October 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Prospects for gene therapy for primary immunodeficiency

Host - Dinakantha Kumararatne

User Adrian Thrasher, UCL, Institute of Child Health, London.

Friday 16 October 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immunology of the thymus: Cellular and molecular aspects

EXTRA TALK ON THURSDAY, 15th Oct. at 14.30hrs - Host Ken Smith

User Georg Holländer, Pediatric Immunology, Center for Biomedicine and The University Children's Hospital of Basel.

Thursday 15 October 2009, 14:30-15:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Integrins and immune function

Host - Chris Rudd

User Nancy Hogg, Cancer Research UK, Lincoln's Inn Fields Laboratories, London.

Friday 09 October 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

New therapies for genetic disease

Host - Linda Wicker

User Peter Goodfellow.

Friday 02 October 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

HIF1 versus HIF2: how macrophages use hypoxic response to regulate nitric oxide

Note different time and day - Host Edwin Chilvers

User Randy Johnson - Division of Biological Sciences, at UCSD.

Tuesday 29 September 2009, 13:15-14:15

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Through the Looking Glass - a New World of Proteins Enabled by Chemistry

User Dr Stephen Kent (Department of Biochemistry and Molecular Biology, University of Chicago).

Monday 28 September 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Can lamprey VLR antibodies be biomedically useful?

Host - Ken Smith

User Max Cooper - Emory University School of Medicine, Atlanta.

Friday 25 September 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How studying responses to Salmonella provides insights into the biology of B and T cells

Host - Kirsten Fairfax

User Adam Cunningham, University of Birmingham.

Friday 18 September 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

NK Cells in reproduction, transplantation and cancer

Extra Talk. Host - Gordon Smith

User Francesco Colucci - Lymphocyte Signalling and Development, The Babraham Institute, plus Centre for Trophoblast Research, University of Cambridge.

Friday 31 July 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Factors influencing the acquisition of CD8+ T cell effector function

EXTRA TALK - Host - Douglas Fearon

User Alice Denton.

Wednesday 29 July 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

From molecules to maladies: TNF superfamily cytokines in autoimmune and inflammatory disease

EXTRA TALK - Host Ken Smith

User Richard Siegel, Senior Investigator and Chief, Immunoregulation Section Autoimmunity Branch, NIAMS National Institutes of Health Bethesda, MD US.

Friday 24 July 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Catch me if you can. Anti HIV restriction factors, viral countermeasures and the Red Queen

Host - Leo James

User Greg Towers, MRC Centre for Medical Molecular Virology, University College London.

Friday 10 July 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Role of aryl hydrocarbon receptor in immune responses

Host - Michael Neuberger

User Marc Veldhoen, NIMR, London.

Friday 03 July 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Visualising and analysing immune priming and infection in real time in vivo

Host -Andrew McKenzie

User James Brewer, Centre for Biophotonics, University of Strathclyde.

Friday 26 June 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Signal sequences in protein targeting to the endoplasmic reticulum

Host Paul Lehner

User Bernhard Dobberstein, ZMBH Universität Heidelberg, Germany.

Friday 19 June 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The influence of signal strength on the differentiation of effector and memory T cells

Host - Gillian Griffiths

User Rose Zamoyska, University of Edinburgh.

Friday 12 June 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Functional genetics of PTPN22, a shared autoimmunity gene

host Linda Wicker EXTRA TALK ON MONDAY

User Nunzio Bottini, Associate Member, La Jolla Institute for Allergy and Immunology, Division of Cell Biology, La Jolla, CA.

Monday 08 June 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Autoimmunity to LAMP-2: a case for molecular mimicry in vasculitis

Host - Ken Smith

User Andrew Rees, Institute of Clinical Pathology, Vienna.

Friday 05 June 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Clues to autoimmunising mechanisms in patients with myasthenia gravis or AIRE mutations

Host - Linda Wicker

User Nick Willcox, Neuroscience, Weatherall Inst. for Molecular Medicine, University of Oxford.

Friday 29 May 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

SLP-76 is mandatory for TCR-mediated inside-out-signaling, but dispensable for CXCR4-mediated LFA-1 adhesion and migration of T-cells

Host - Chris Rudd

User Stefanie Kliche.

Friday 22 May 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The biology of 'atypical' chemokine receptors

Host - Alex Betz

User Rob Nibbs, Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre.

Friday 15 May 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transcriptional networks in macrophages

Host - Paul Lyons

User David Hume, Roslin Institute, Edinburgh.

Friday 08 May 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting regulatory T cells in rheumatoid arthritis

Host - Douglas Fearon

User Michael Ehrenstein, UCL, London.

Friday 01 May 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tolerance, autoimmunity and interleukin-2

Host John Todd

User Abul Abbas, University of California.

Friday 24 April 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Amphioxus immunity provides the ancestral form and inner workings of vertebrates immune system

This talk has been cancelled

User Aniong Xu, Sun Yat-sen University, Guangzhou.

Friday 27 March 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Roles of PD-1 and PD-L1 in regulating T cell activation and tolerance

This is an extra NIT seminar being held on a Wednesday at 12.30pm

User Arlene Sharpe, Dept of Pathology, Harvard Medical School.

Wednesday 25 March 2009, 12:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Inhibitors of innate immunity from vaccinia virus

User Geoff Smith, Imperial College, London.

Friday 13 March 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Preserving and restoring gut barrier function

User Simon Carding, University of East Anglia.

Friday 06 March 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Regulatory B cells in health and in disease

User Claudia Mauri.

Friday 27 February 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cancelled

This talk has been cancelled

User Duncan Conrad.

Friday 20 February 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Learning about innate immune signalling from viruses

User Andrew Bowie, Trinity College, Dublin.

Friday 13 February 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Complement genetic variations and disease. Functional and Structural insights into the assembly and regulation of the alternative pathway C3-convertase

User Santiago Rodriguez de Cordoba, Centro de Investigaciones Biologicas (CSIC) Madrid.

Friday 30 January 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Restriction of enveloped virus particle release by tetherin/CD317

User Stuart Neil, Kings College, London.

Friday 23 January 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Effector differentiation during development of the memory CD8+ T cell

User Douglas Fearon, Wellcome Immunology Unit, University of Cambridge.

Friday 16 January 2009, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Peptide-based immunotherapy for coeliac disease

User Bob Anderson, Walter & Eliza Hall Institute, Melbourne, Australia.

Friday 05 December 2008, 13:00-14:00

lvb23's list

Delineating the Fanconi Anaemia DNA Repair Defect

User Dr K J Patel: MRC Laboratory of Molecular Biology.

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Tuesday 02 December 2008, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cohesin, CTCF and gene regulation in the immune system

User Matthias Merkenschlager, MRC Clinical Sciences Centre, London.

Friday 21 November 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The intracellular biology of Salmonella

User David Holden, Imperial College, London.

Friday 14 November 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How does CTLA-4 control T cell activation? A story of Treg and regular Ts

User David Sansom, University of Birmingham.

Friday 07 November 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cell death inhibitors: from Baculovirus to Bedside

Please note change of day - WEDNESDAY and time 12.00 noon

User David Vaux, Latrobe University, Melbourne, Australia.

Wednesday 05 November 2008, 12:00-13:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Immunity to self co-generates regulatory T cells

Please note change of day - THURSDAY

User Len Harrison, Walter and Eliza Hall Institute of Medical Research, Melbourne.

Thursday 30 October 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Matching Lymphocyte Metabolism and Migration

User Doreen Cantrell, Cell Biology and Immunology, University of Dundee.

Friday 24 October 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Targeting HIV-1 Gag into the DRiP-pathway enhances its presentation by MHC class I

Canceled

User Ulrich Schubert, University of Erlangen, Germany.

Friday 17 October 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Rational vaccine design – dreams, genes and reality

Please note this is an extra seminar on THURSDAY AT 14.30HRS

User Alex von Gabain, Intercell AG, Vienna.

Thursday 16 October 2008, 14:30-15:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The genetic basis of ankylosing spondylitis

User Matt Brown, University of Queensland, Brisbane.

Friday 10 October 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Regulators, some 'complement'ary stories

User Susan Lea, Sir William Dunn School of Pathology, Oxford.

Friday 03 October 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Lymphocyte egress: from S1P to Arp2/3

User Jason Cyster, Howard Hughes Medical Centre, UCSF.

Friday 26 September 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Pathogenesis of Autoimmunity: The IL-2-FOX P3 Negative Feedback Pathway

Note unusual time

User Kendall Smith.

Friday 26 September 2008, 10:30-11:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cell-biology of antigen cross-presentation

User Christian Kurts, Friedrich-Wilhelms-Universität, Bonn, Germany.

Friday 19 September 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Novel approaches for vaccine design: Bypassing Treg activity enhances T cell-mediated immunity

User Tim Sparwasser, Institut fur Medizinische Mikrobiologie, Immunologie und Hygiene, Munich.

Friday 11 July 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

How Satan smote Job: The molecular cause of the hyper IgE syndrome - Are th17 cells really the bad guys?

User Bodo Grimbacher, Clinical Immunology, Royal Free Hospital, London.

Friday 04 July 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Understanding genetics of type 1 diabetes: from common to rare disease variants

User Sergey Nezhentsev, CIMR, University of Cambridge.

Friday 27 June 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Microarrays to identify human Th1 and Th2-specific effector molecules

User David Cousins, MRC/Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London.

Friday 20 June 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Transplantation tolerance - strategies to promote and biomarkers to measure

User Robert Lechler, Vice Principal (Health), Guys Campus, King's College London.

Friday 13 June 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Perturbation of the ubiquitin-proteasome system in Epstein-Barr virus infection and oncogenesis

User Maria Masucci, Dept of Cell and Molecular Biology, Karolinska Institute, Sweden.

Friday 06 June 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Pathophysiology of Autoimmune Disease

User David Hafler, Centre for Neurologic Diseases, Harvard medical School, Boston, USA.

Friday 30 May 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

'A crystal structure based study of NhaA, a Na+/H+ antiporter with orthologues from bacteria to human'

http://www.mrc-dunn.cam.ac.uk/news/seminars.php

User Professor Etana Padan, Hebrew University of Jerusalem, Israel.

Wednesday 28 May 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

'Light triggers for visualization of signal protein dynamics'

http://www.mrc-dunn.cam.ac.uk/news/seminars.php

User Professor Shahid Khan, School of Science and Engineering, Lahore, Pakistan and Molecular Biology Consortium, Chicago, USA.

Tuesday 27 May 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Take your pick - epitope selection by effector and regulatory T cells in autoimmune disease

User Rob Barker, Head of Immunology Programme, Inst. of Medical Sciences, University of Aberdeen.

Friday 23 May 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

'Construction of the bacterial flagellar rotor

http://www.mrc-dunn.cam.ac.uk/news/seminars.php

User Professor Shahid Khan, LUMS School of Science and Engineering, Lahore, Pakistan and Molecular Biology Consortium, Chicago, USA.

Thursday 22 May 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

'The motile response of bacteria to pH jumps'

http://www.mrc-dunn.cam.ac.uk/news/seminars.php

User Professor Shahid Khan, LUMS School of Science and Engineering, Lahore, Pakistan and Molecular Biology Consortium, Chicago, USA.

Wednesday 21 May 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Toll-like receptor signal transduction in infection and inflammation

User Luke O'Neill, Trinity College, Dublin.

Friday 16 May 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

'Mitochondrial FAS - from respiratory deficient yeast to cardiomyopathic mice'

http://www.mrc-dunn.cam.ac.uk/news/seminars.php

User Professor Kalervo Hiltunen, University of Oulu, Finland.

Wednesday 14 May 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Give us the tools, and we will finish the job

User Stephen Sawcer, Dept of Clinical Neurosciences, University of Cambridge.

Friday 09 May 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cytomegalovirus latency, reactivation and life and death decisions

User John Sinclair, Dept of Medicine, University of Cambridge.

Friday 02 May 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

A crystal structure based study of NhaA, a Na+/H+ antiporter with orthologues from bacteria to human

http://www.gurdon.cam.ac.uk/events.html

User Etana Padan, Hebrew university of Jerusalem, Israel.

Monday 28 April 2008, 16:00-17:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mitochondrial adaptation to high altitude hypoxia

http://www.gurdon.cam.ac.uk/events.html

User Andrew Murray, Department of Physiology, Development and Neuroscience.

Monday 28 April 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Mitochondrial FAS - from respiratory deficient yeast to cardiomyopathic mice

http://www.gurdon.cam.ac.uk/events.html

User Kalervo Hiltunen, university of Oulu, Finland.

Monday 14 April 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

CD3 monoclonal antibodies to treat type 1 diabetes

User Lucienne Chatenoud, INSERM, Hopital Necker, Paris, France.

Friday 11 April 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Foxp3: evolution, pregnancy, therapy

User Alex Betz, MRC-LMB, Cambridge.

Friday 04 April 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Socs in myeloproliferative disease

Nephrology, Immunology & Transplantation seminars

User Jim Johnston, Queens University, Belfast.

Friday 14 March 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

The Vav1 nucleotide exchange factor: from structure to function

Nephrology, Immunology & Transplantation seminars

User Victor Tybulewicz Nat. Inst. for Medical Research.

Friday 07 March 2008, 13:00-14:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Monitoring single ion transporters at work: proton-driven rotation in FoF1-ATP synthase and domain swapping in P-type ATPase

MRC Dunn Human Nutrition Unit

User Dr Michael Börsch University of Stuttgart, Germany.

Tuesday 04 March 2008, 15:00-16:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Discussion over lunch

User All Invited (please let me know for numbers).

Friday 22 February 2008, 12:30-13:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Discussion

User ALL.

Friday 22 February 2008, 12:20-12:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Molecular dynamics simulations of protein-surface interactions

User Daniel Cole, Cavendish Laboratory.

Friday 22 February 2008, 12:10-12:20

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Statistical methods in X-ray crystallography

User Professor Randy Read, CIMR.

Friday 22 February 2008, 12:00-12:10

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Serpin metastability and protease inhibition

User Dr James Huntington.

Friday 22 February 2008, 11:50-12:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Discussion

User All.

Friday 22 February 2008, 11:40-11:50

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Modelling semiflexible chains, filaments, and their networks

User Professor Eugene Terentjev, Cavendish Laboratory, University of Cambridge.

Friday 22 February 2008, 11:30-11:40

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Investigating incretin hormone secretion by single cell dynamic fluorescence imaging.

User Dr Fiona Gribble, CIMR.

Friday 22 February 2008, 11:20-11:30

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Optical micromanipulation and quantifying Images

User Dr Pietro Cicuta, Cavendish Laboratory (University of Cambridge).

Friday 22 February 2008, 11:10-11:20

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Intracellular function and motor properties of myosin VI

User Dr Folma Buss, CIMR.

Friday 22 February 2008, 11:00-11:10

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Coffee Break

User All.

Friday 22 February 2008, 10:45-11:00

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Discussion

User All.

Friday 22 February 2008, 10:35-10:45

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Nucleic acid structures - predicting formation and function

User Julian Huppert, Cavendish Laboratory (University of Cambridge).

Friday 22 February 2008, 10:25-10:35

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Incretin secretion - small currents matter.

User Dr Frank Reimann, CIMR.

Friday 22 February 2008, 10:15-10:25

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cell fate in the mammalian epidermis

User Ben Simons (University of Cambridge).

Friday 22 February 2008, 10:05-10:15

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Discussion

User All.

Friday 22 February 2008, 09:55-10:05

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Autophagy upregulation - a possible therapeutic strategy for neurodegenerative conditions like Huntington's disease

User Professor David Rubinsztein, CIMR.

Friday 22 February 2008, 09:45-09:55

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Soft Matters - biomechanics in cancer diagnosis and nerve regeneration

User Dr. Jochen Guck, Cavendish Laboratory (University of Cambridge).

Friday 22 February 2008, 09:35-09:45

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Antitrypsin deficiency and the serpinopathies

User Professor David A Lomas, CIMR.

Friday 22 February 2008, 09:25-09:35

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Cells and gels - questions a physicist asks

User Professor Athene Donald, Director, Physics of Medicine, Cavendish Laboratory.

Friday 22 February 2008, 09:15-09:25

House Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research.

Introduction

User Professor Paul Luzio, Director of CIMR.

Friday 22 February 2008, 09:10-09:15