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Genome architecture and chromatin regulation in C. elegans

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All nuclear events take place in the context of chromatin, the organization of genomic DNA with histones and hundreds of associated proteins and RNAs. Regulating the composition and structure of chromatin controls transcription and other nuclear processes, and is important for cell fate decisions, the expression of cell identity, the maintenance of pluripotency, and the transformation to cancer. We use C. elegans to study chromatin regulation in gene expression and genome organization in a whole organismal context, because it has a complement of core chromatin factors very similar to that of humans, a small well-annotated genome (30x smaller than human), RNAi for loss of function studies, and well-characterised cell fates. I will discuss our work on the properties and activities of promoters and enhancers, the regulation and function of chromatin domains, and interactions between regulatory elements.

This talk is part of the Computational and Systems Biology series.

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