Using C. elegans to learn principles of eukaryotic chromatin regulation

Add to your list(s) Download to your calendar using vCal

• Julie Ahringer, The Gurdon Institute, University of Cambridge
• Wednesday 02 March 2016, 14:00-15:00
• MR4, Centre for Mathematical Sciences, Wilberforce Road, Cambridge.

If you have a question about this talk, please contact Emily Boyd.

All nuclear events take place in the context of chromatin, the organization of genomic DNA with histones and hundreds of associated proteins and RNAs. Regulation of the composition and structure of chromatin controls transcription and other nuclear processes, and is important for cell fate decisions, the expression of cell identity, the maintenance of pluripotency, and the transformation to cancer. However, our knowledge of chromatin structure and function is still at a basic level. We use C. elegans to address these questions because it has a complement of core chromatin factors very similar to that of humans, a small well-annotated genome (30x smaller than human), RNAi for loss of function studies, and well-characterised cell fates. I will discuss our work on transcription regulation and genome organization, such as properties and activities of promoters and enhancers, and principles of genome organization inferred from chromatin state mapping.

This talk is part of the Computational and Systems Biology series.

This talk is included in these lists:

• All CMS Events
• All Talks (aka the CURE list)
• Biology
• CamBridgeSens
• Cambridge Infectious Diseases
• Cambridge talks
• Computational and Systems Biology
• Graduate-Seminars
• Life Science Interface Seminars
• Life Sciences
• Life Sciences
• ME Seminar
• MR4, Centre for Mathematical Sciences, Wilberforce Road, Cambridge
• PMRFPS's
• School of Physical Sciences
• Trust & Technology Initiative - interesting events
• custom
• my_list
• other talks
• se393's list

Note that ex-directory lists are not shown.