University of Cambridge > > Adrian Seminars in Neuroscience > "Plastic Transcriptomes and Proteomes at Synapses"

"Plastic Transcriptomes and Proteomes at Synapses"

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If you have a question about this talk, please contact Lyn Dakin.

“Protein synthesis is a dynamic process that tunes the cellular proteome in response to internal and external demands. Metabolic labeling approaches identify the general proteomic response but cannot visualize specific newly synthesized proteins within cells. Here we describe a technique that couples noncanonical amino acid tagging or puromycylation with the proximity ligation assay to visualize specific newly synthesized proteins and monitor their origin, redistribution and turnover in situ.”

“The elaborate morphology of neurons together with the information processing that occurs in remote dendritic and axonal compartments makes the use of decentralized cell biological machines necessary. Recent years have witnessed a revolution in our understanding of signaling in neuronal compartments and the manifold functions of a variety of RNA molecules that regulate protein translation and other cellular functions. Here we discuss the view that mRNA localization and RNA -regulated and localized translation underlie many fundamental neuronal processes and highlight key issues for future experiments.”

This talk is part of the Adrian Seminars in Neuroscience series.

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