Structure of TRP channel by single particle cryo-EM

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• Yifan Cheng
• Wednesday 16 March 2016, 11:00-12:00
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

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The Transient Receptor Potential (TRP) ion channel is a large and functionally diverse superfamily, second only to the potassium channels. Members of TRP channel superfamily include the capsaicin receptor, TRPV1 , and the “wasabi” receptor, TRPA1 . TRPV1 is a polymodal signal detector that resides on primary afferent sensory neurons. It is a heat-activated cation channel that is also modulated by various inflammatory agents and contributes to acute and persistent pain. TRPA1 activation is triggered by various pungent agonists such as allyl-isothiocyanate from mustard and allicin from garlic, both generating pungent taste. Enabled by recent technological breakthroughs in single particle cryo-EM, we determined the atomic structures of both TRPV1 and TRPA1 . We also utilized their rich pharmacological information for structural investigation of these two channels in various functional states, aiming to elucidate the mechanism of channel activations.

This talk is part of the MRC LMB Seminar Series series.

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