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Spindle Orientation in Epithelial Cells

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The orientation in which a cell divides is determined by the angle of the mitotic spindle. Spindle orientation is well studied in asymmetrically-dividing cells, like Drosophila neuroblasts, which use oriented divisions to determine daughter cell fate. Less attention has been paid to the spindle orientation in symmetrically-dividing epithelial cells, which orient divisions to build and maintain epithelial sheets. My work in the St Johnston lab is focused on two questions: 1) How does spindle orientation work in these tissues? 2) What happens when it doesn’t?

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