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Evolution of Bacterial Genomic Networks

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If you have a question about this talk, please contact Nicholas Luscombe.

Two major forces by which bacterial populations adapt are gain and loss of genes. In order to understand these processes, it is necessary to analyse them in a systemic context. We chose E. coli as our model system, as it is one of the best studied cellular systems, and because of the availability of experimentally verified simulation methods for its metabolic network. How and why did E. coli’s metabolic network change in the course of evolution? What is the contribution of horizontal transfer of genes between unrelated strains? What forces affect the fixation and integration of new genes into their host? Can we make quantitative predictions about the course of reductive evolution in endosymbionts? These are some of the questions that I will answer during my talk.

This talk is part of the European Bioinformatics Institute series.

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