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Evolving technologies for liver targeted gene and cell therapies.

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  • UserProfessor Ian Alexander, Professor in Paediatrics & Molecular Medicine, Disciplines of Paediatrics and Child Health and Genetic Medicine, The Children's Hospital at Westmead, World_link
  • ClockWednesday 08 October 2014, 16:15-17:15
  • HouseLecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Fiona Roby.

Genetic and acquired diseases of the liver are collectively prevalent and remain challenging to treat, with the most severe phenotypes necessitating liver transplantation for long term survival. Evolving therapeutic modalities, such as liver targeted gene and cell therapy, are therefore of immense research interest, and are show exciting early therapeutic promise. This seminar will explore the rapidly developing technologies available for genetic manipulation of the liver, taking into account the liver’s unique biology and disease-specific requirements for therapeutic effect. The convergence of gene and cell therapy will also be examined, in particular strategies for selective in vivo expansion of therapeutic hepatocyte sub-populations. This in turn opens the prospect of curing genetic liver disease by targeted genome editing rather than by contemporary gene addition strategies

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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