University of Cambridge > Talks.cam > Bradford Hill Seminars > Revisiting the use of families in complex genetic disease studies

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Revisiting the use of families in complex genetic disease studies

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Lucy Lloyd.

BRADFORD HILL SEMINAR

Professor Sylvia Richardson, Director of the MRC Biostatistics Unit, will introduce Professor Cordell.

Traditionally, genetic studies have focussed on using data from families (related individuals) in order to track the inheritance patterns of genetic material through a pedigree. In the last few years, there has been a shift in emphasis towards analysis of unrelated individuals, for example in large-scale genome-wide association studies involving population-based cohorts of unrelated cases and controls. In this talk I shall illustrate the utility of family-based collections for identifying genetic determinants of complex disease with reference to three ongoing projects: (1) an investigation of methods/software to correct for relatedness between individuals in genome-wide association studies, with particular application to a Brazilian family study of visceral leishmaniasis; (2) linkage/association mapping in an affected sib pair study of vesicoureteric reflux; (3) improving the power for detection of parent-of-origin effects in case/parent trios through haplotype estimation.

This talk is part of the Bradford Hill Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Graduate Development Lecture Series Beyond Profit Enterprise Stream Wolfson Research Event Andrew Chamblin Memorial Lecture 2016 tate modern

Other talks

Towards a whole brain model of perceptual learning A stochastic model for understanding PIN polarity in isolated cells Power to the People – Creating Markets for Supply Security Based on Consumer Choice Deep & Heavy: Using machine learning for boosted resonance tagging and beyond What sort of challenge is climate change? Fifty years of editorialising in ‘Nature’ and ‘Science’ MOVED TO 28 JUNE 2018 It takes two to tango:platelet collagen receptor GPVI-dimer in thrombosis and clinical implications Discovering regulators of insulin output with flies and human islets: implications for diabetes and pancreas cancer The Partition of India and Migration The Gopakumar-Vafa conjecture for symplectic manifolds 'Cambridge University, Past and Present' LARMOR LECTURE - Exoplanets, on the hunt of Universal life The role of transcription factors in cancer
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity