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Intrinsic biophysical diversity and connectivity of neuronal circuits

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A neuron’s intrinsic biophysical profile together with its anatomical and functional connectivity defines its function. Although different classes of neurons are known to express different constellations of membrane channels, very few studies have quantified such biophysical diversity across the population of a single class. I will present recent data obtained from principal cells in the olfactory bulb investigating the relationship between the biophysical profile of an individual neuron and its function. In the second part of the talk I will describe our recently developed tool that enables us to assess the biophysical and sensory properties of an individual neuron in vivo, then to trace the upstream connectivity profile of that cell. We have implemented a fully automated serial two-photon microscope that facilitates high-throughput analysis of large-scale connectivity datasets. This will allow us to establish a three-dimensional functional connectivity atlas of single cells and information pathways in the brain.

This talk is part of the MRC LMB Seminar Series series.

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