|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Multiparametric MRI of the vasculature: applications to therapy monitoring of gliomas
If you have a question about this talk, please contact Laura Blackburn.
Microvascular alterations have been observed in numerous brain pathologies, including brain tumours, brain ischemia, brain trauma and neurodegenerative diseases. Vascular density, morphology, permeability and reactivity as well as blood volume, flow and oxygenation may be affected. Characterization of these modifications may be of clinical interest for diagnosis, prognosis, treatment planning, and therapeutic follow-up. From a more fundamental point of view, this characterization may be useful for improving our understanding of the mechanisms underlying the evolution of these pathologies or the action of new therapies. The team has developed novel MRI methods to map the characteristic parameters of the cerebral microvasculature: blood volume, vessel diameters, and oxygenation. These methods were validated on healthy animal and bearing intracerebral gliomas. An integration of these methods with diffusion imaging, blood flow and permeability to two different contrast agents offer a multiparametric imaging protocol of the vasculature (duration 1h15min). We evaluated the interest of each of these parameters as indicators of therapeutic effect on glioma models in rats in the case of an antiangiogenic therapy (sorafenib) and an innovative method of radiotherapy, synchrotron microbeam radiation. Multiparametric MRI appears as an imaging modality with a high potential for preclinical evaluation of new therapeutic strategies and clinical as an indicator of therapeutic effect. The clinical transfer of these methods is in progress.
This talk is part of the CRI Imaging Seminars series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsNeuroscience Seminars POLIS events and lectures CU Caving Club talks
Other talksInferno XVII, Purgatorio XVII, Paradiso XVII The minimum modulus of a covering system is at most 10^19 Rethinking the European Union Vitamin B12 - A Synthesis Regulation of calcium homeostasis in myeloid cells: new therapeutic targets in inflammation Direct Rail Services: Railway Freight Growth and Investiment